乙酰肝素酶与动脉粥样硬化

Heparanase and atherosclerosis

乙酰肝素酶（heparanase，HPA）是哺乳动物体内唯一降能解细胞外基质中硫酸乙酰肝素蛋白多糖的β—D-葡萄糖醛酸内切酶。近年来的相关研究表明，HPA与动脉粥样硬化斑块的形成和发展密切相关，并且与斑块从稳定向不稳定的转化有关。文章就HPA在动脉粥样硬化进展过程中促进斑块内炎症反应、与蛋白水解酶协同作用以及参与血液高凝状态等方面的相关研究进展进行了综述。

Heparanase （HPA） is a β-D-endoglycosidase of the only degradation of heparan sulfate proteoglycans in extracellular matrix in mammals. The related studies in recent years have suggested that HPA is closely associated with the formation and development of atherosclerotic plaques, and may be associated with the conversion from stable to unstable plaques. This article reviews the related studies of HPA in atherosclerosis progession, such as promoting plaque inflammatory response, synergy with proteolytic enzymes, and involving in hypercoagulable states, etc.