涎腺腺样囊性癌中相关抑癌基因的研究进展

Research Progress in Tumor Suppressor Gene of Salivary Adenoid Cystic Carcinoma

涎腺腺样囊性癌(ACC)是一种发病率较高的涎腺恶性肿瘤,具有嗜神经侵袭和肺转移特性,其发生和发展是多个基因及产物共同作用的结果。传统治疗的效果并不理想,大量的临床研究已初步证实,ACC的癌细胞中存在多个抑癌基因启动子区的高甲基化,从而使细胞失去调控呈无限增殖。目前所研究的基因大多涉及癌细胞的发生、黏附、周期调控和信号转导等方面,对这些基因的研究关系到肿瘤的诊断、治疗及预后评价。

Salivary adenoid cystic carcinoma（ACC） is one of the malignant salivary glands tumors with perineuralinvasion,lung metastasis and high incidenee. Its occurrence and development are the result of the interaction of multiple genes and their products. Traditional treatments is diseontent, A large number of clini-cal studies have initially confirmed that ACC cells have hypermethylatlon of promoter regions of muitiple tumor suppressor genes, which msuhs in that the loss of the cells regulation and unlimited proliferation. Currently researched genes are mostly related to the tumorigenesis, adhesion, cycle regulation and signal transduetion of the cancer cells. Studying these genes can affect the diagnosis, treatment and prognostie evalu- ation of the tumor.