摘要
目前,国内外对乳腺癌的有关基因表达的大量研究表明,CD24、CD44参与了乳腺癌的浸润、转移过程,增殖细胞核抗原(PCNA)被认为是乳腺癌的重要预后因子。相关研究主要涉及CD24、CD44及PCNA的生物学特性、各自与乳腺癌的关系等,目的在于分析三者联合检测对乳腺癌的影响,对CD24、CD44及PCNA在乳腺癌的发生和发展、增殖及转移的机制方面作更加深入的研究,以进一步研究证实三者的联合检测对乳腺癌的治疗及预后是否可提供临床参考价值等。
At present,a large number of studies have been done on the expression of breast cancer both domestically and abroad. ,which indicated CD24 and CD44 participate the process of invasion and metastasis in breast cancer. PCNA was considered as an important factor of prognosis in breast cancer. The related researches are mainly with regards to biological feature of CD24, CD44 and PCNA, the relationship between the three markers and breast cancer,to analyze the influence of combined test on breast cancer. Some more in-depth researches have beendone in the mechanisms of CD24, CD44 and PCNA in occurrence, development, proliferation and metastasis of breast cancer, to demonstrate if the unified detection of expression of CD24, CD44 and PCNA in breast cancer have clinical instructive significance in the treatment and prognosis. n
出处
《医学综述》
2013年第18期3321-3323,共3页
Medical Recapitulate
