细辛脑联合氨溴索治疗婴幼儿支气管肺炎的临床疗效分析

Analysis of the Clinical Curative Effect of Asarone Combined with Ambroxol Treatment for Infant Bronchial Pneumonia

目的 分析并探讨细辛脑联合氨溴索治疗婴幼儿支气管肺炎的临床疗效.方法 将海军总医院儿科自2009年12月至2012年12月收治的108例支气管炎住院患儿采用随机数字表法分为两组,每组54例,均在入院后实施综合治疗措施,包括吸氧、镇静、吸痰、雾化吸入、使用抗生素以及在必要时使用糖皮质激素等治疗措施.观察组在实施以上综合治疗的前提下再加用盐酸氨溴索注射液[7.5 mg盐酸氨溴索溶入5 ～10%葡萄糖注射液30 ～50 mL中,静脉滴注],每日2次,7 ～10 d为一个疗程,再经静脉滴注细辛脑注射液[1 mg/（kg·d）,用5% ～10%葡萄糖注射液稀释为0.01% ～0.02%的浓度,静脉滴注],每日1次,连续应用5 ～7 d.治疗结束后对比分析两组患儿的退烧时间、喘气缓解时间、咳嗽消失时间、哮鸣音消失时间、湿啰音消失时间以及住院天数.观察两组的口干及恶心等不良反应情况.结果 观察组患儿的显效率与总有效率均显著优于对照组（P＜0.05）.观察组与对照组相比,患儿在退烧时间[（1.7±1.1） d vs（2.4±1.1） d]、喘气缓解时间[（4.4±1.5） d vs（4.9±1.7） d]、咳嗽消失时间[（5.4±1.4） d vs（6.6±1.6） d]、哮鸣音消失时间[（4.2±3.1） d vs（6.3±3.2） d]、湿啰音消失时间[（4.7±3.2） d vs（6.6±2.9） d]以及住院天数[（7.0±2.5） d vs（9.0±2.5） d]均少于对照组,比较差异均有统计学意义（P＜0.05）.结论 细辛脑联合氨溴索对婴幼儿支气管肺炎的临床疗效确切,无明显不良反应,提倡临床推广应用.

Objective To analyze and evaluate the clinical curative effect of asarone combined with am-broxol on infant bronchial pneumonia. Methods A total of 108 cases of bronchitis admitted by Navy General Hospital from December 2009 to December 2012 were divided into two groups, by table of random number principle. Each group had 54 cases, the implementation of comprehensive treatment measures were carried out in the hospital, including oxygen, sedation, sputum suction, inhalation, use of antibiotics and glucocorticoid when necessary. On the basis of the above comprehensive treatment, the observation group was added with ambroxol hydrochloride injection 2 times a day （7.5 mg ambroxol hydrochloride into 5%-10% and 30-50 mL glucose injection,intravenous drip） ,for a period of 7-10 d,and then by intravenous given asarone injection [ 1mg/（ kg · d） ,with 5% -10% glucose injection diluted to concentrations of 0.01%-0.02% , intravenous drip ], 1 time a day, for 5-7 d continuously. After the end of treatment, fever time, panting relief time, cough disappearance time, wheeze disappearance time, moist rales disappearanee time and hospitalization time of the two groups were compared. Adverse reaction such as dry mouth and nausea uf the two groups were observed. Results The markedly effective rate and total effective rate of the observation group were better than the control group（ P 〈 0.05 ） ,with statistically significant difference. Data uf the observation group and the eon-trol group were ： fever remissiun time [ （ 1.7 ±1. 1 ） d vs （2.4 ±1. 1 ） d ] , panting disappearance time [ （4.4 ±1.5） dvs （4.9±1.7） d],cough disappearance time[（5.4±1.4） d vs （6.6±1.6） d] , wheezing disappearance time[ （4.2 ± 3.1 ） d vs （6.3 ± 3.2 ） d ] , moist rales disappearanee time [ （ 4.7 ± 3.2 ） d vs （6.6 ± 2.9 ） d ] and hospital slay [ （ 7.0 ± 2.5 ） d vs （9.0 ± 2.5 ） d ], the observation group were better than the control group with statistically significant difference （ P 〈 0.05 ）. Conclusion Asarone combined with ambruxol clinical curative effect on infant bronchial pneumonia is exact,without obviuus adverse reae-lion ,worth of clinical application.