AMPK在体育锻炼干预Ⅱ型糖尿病中的作用机理被引量：4

The Mechanism of AMPK in Physical Exercise Intervention for Non-insulin Dependent Diabetes Mellitus

下载PDF

导出

摘要腺苷酸激活蛋白激酶(AMPK)作为体内"能量感受器",可通过其激活下游靶蛋白调节机体糖、脂代谢。目前许多降糖药均是通过激活体内AMPK通路降低血糖水平。运动作为激活AMPK的刺激已被广泛认同。综述近年来关于急、慢性等不同运动组合对AMPK、AMPK各亚单位活性、下游调节蛋白的影响及降低血糖的效果,通过体育锻炼预防、治疗Ⅱ型糖尿病。 AMP-activated -Protein Kinase （ AMPK ）, as the sensor of energy in the body, can regulate glycol-metabolism and lipid metabolism through activating its downstream protein. At present, most hypoglycemic agents aimed to decreased glucose level depend on this pathway. It has been widely confirmed for physical exercise to be the stimulus of activating AMPK. The study reviewed the effects of acute and chronic physical exercises on the activity of AMPK, the subunits of AMPK and its downstream protein, indicating that physical exercises prevent and treat non-insulin dependent diabetes mellitus （NIDDM）.

作者王守都刘海平

机构地区温州医科大学体育科学学院

出处《上海体育学院学报》 CSSCI 北大核心 2013年第5期84-88,共5页 Journal of Shanghai University of Sport

关键词 Ⅱ型糖尿病腺苷酸激活蛋白激酶体育锻炼作用机理 non-insulin dependent diabetes mellitus 5＇-AMP-activated -Protein Kinase physical exercise function mechanism

分类号 G804.2 [文化科学—运动人体科学]

引文网络
相关文献

参考文献39

1Kamysheva E P.Insulinoresistance in Internal Diseases[J].Klin Med(Mosk),2007,85(6):21-27.
2Blickle J F,Doucet J,Krummel T,et al.Diabetic Nephropathy in the Elderly[J].Diabetes Metab,2007,33(1):40-55.
3杨航,杨吉春,管又飞.AMPK在机体糖脂代谢中的作用[J].生理科学进展,2009,40(3):249-252. 被引量：10
4Johannes C B,Koro C E,Quinn S G,et al.The Risk of Coronary Heart Disease in Type 2 Diabetic Patients Exposed to Thiazolidinediones Compared to Mefformin and Sulfonylurea Therapy[J].Pharmacoepidemiol Drug Saf,2007,16(5):504-512.
5Scott J W,Ross F A,Liu J K,et al.Regulation of AMP-Activated Protein Kinase by a Pseudosubstrate Sequence on the Gamma Subunit[J].EMBO J,2007,26 (3):806-815.
6Stapleton D,Mitchelhill K I,Gao G,et al.Mammalian AMP-Activated Protein Kinase Subfamily[J].J Biol Chem,1996,271 (2):611-614.
7Iseli T J,Walter M,van D B J,et al.AMP-Activated Protein Kinase Beta Subunit Tethers Alpha and Gamma Subunits via Its C-Terminal Sequence(186-270)[J].J Biol Chem,2005,280(14):13395-13400.
8Polekhina G,Gupta A,van D B J,et al.Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase[J].Structure,2005,13(10):1453-1462.
9Schimmack G,Defronzo R A,Musi N.AMP-Activated Protein Kinase:Role in Metabolism and Therapeutic Implications[J].Diabetes Obes Metab,2006,8(6):591-602.
10Shaw R J,Kosmatka M,Bardeesy N,et al.The Tumor Suppressor LKB1 Kinase Directly Activates AMP-Activated Kinase and Regulates Apoptosis in Response to Energy Stress[J].Proc Natl Acad Sci U S A,2004,101(10):3329-3335.

二级参考文献9

1Johannes CB, Koro CE, Quinn SG, et al. The risk of coronary heart disease in type 2 diabetic patients exposed to thia- zolidinediones compared to metformin and sulfonylurea therapy. Pharmacoepidemiol Drug Saf,2007,16 : 504 - 512.
2Kim WH, Lee JW,Suh YH, et al. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cell Signal,2007,19 : 791 - 805.
3Kim YD, Park KG, Lee YS, et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase dependent regulation of the orphan nuclear receptor SHP. Diabetes,2008,57 : 306 - 314.
4Shaw RJ, Lamia KA, Vasquez D, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science,2005,310 : 1642 - 1646.
5Foretz M, Ancellin N, Andreelli F, et al. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes,2005,54 : 1331 - 1339.
6Daval M, Dupuy FD, Bazin R, et al. Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem,2005,280 : 25250 - 25257.
7Jorgensen SB, Nielsen JN, Birk JB, et al. The α2-5'-AMP- activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading. Diabetes,2004,53 : 3074 - 3081.
8Kim MS, Park JY, Namkoong C, et al. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med,2004, 10 : 727 733.
9Lee WJ, Song KH, Koh EH, et al. A-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun,2005,332 : 885-891.