无痉挛电休克治疗对抑郁症患者记忆的影响

A study on effect of Modified Electroconvulsive Therapy on memory of patients with depression

目的探讨无痉挛电休克治疗(MECT)对抑郁症患者记忆功能的影响。方法对49名符合无痉挛电休克治疗标准的抑郁症住院患者行3周无痉挛电休克治疗,每周3次。分别于治疗前、治疗1周末、治疗2周末和治疗3周末行加利福尼亚言语学习测验(CVLT)和韦氏记忆量表(WMS)测验,以考察患者的记忆功能。结果治疗1、3周后CVLT评分与治疗前比较,差异有统计学意义(P<0.05或0.01);但治疗第2周末,CVLT评分除自由回忆总分和短时自由回忆评分外,其余因子分与治疗前比较差异均无统计学意义(P#0.05)。治疗后第1周末,除积累、图片、再认因子外,其余因子评分与治疗前比较差异有统计学意义(P<0.05);治疗第2周末,WMS评分与治疗前比较差异无统计学意义(P#0.05);治疗第3周末,除积累、背数、MQ因子外,其余因子评分与治疗前比较差异有统计学意义(P<0.05或0.01)。结论无痉挛电休克可能短时间内影响患者的记忆功能,但持续的MECT可能有助于患者的记忆恢复。

Objective To study the clinical effect of Modified Electroconvulsive Therapy （MECT） on memory of patients with depression. Methods 49 patients were selected as the study group. They received MECT three times per week, and then assessed their memory by the California Verbal Learning Test （CVLT） and the Wechsler Memory Scale （WMS） before and after 1 week , 2 weeks and 3 weeks treatment of MECT. Results Both of the scores of CVLT and WMS before the treatment were statistically different from that after the treatment, and most of the items in CVLT and WMS were different from the 1 st week and before ; most of which were significantly enhanced than that of before ; while the 2nd week period had not apparently changed than before. Conclusion The sustained utilization of MECT probably has significant effect on improving the function of memory in patients with depression, although it had negative influence on the early stage.