全麻患者术前焦虑评分与丙泊酚诱导参数的相关性

Correlation between preoperative anxiety score and induction parameters with propofol in patients undergoing general anesthesia

目的评估全麻患者术前焦虑评分与丙泊酚靶控输注(TCI)诱导过程中患者意识消失(LOC)所需时间和丙泊酚效应室浓度(Ce)的相关性。方法选择拟于全麻下行择期妇科手术的患者,术前对患者进行焦虑评分。患者入室后给予丙泊酚TCI,目标血浆浓度设为4 mg/L。记录患者对大声呼唤无反应(LOC)所需的时间和丙泊酚的Ce。采用Pearson相关性分析研究术前焦虑评分和两者的相关性。结果中度和重度焦虑患者的LOC所需时间和丙泊酚Ce均显著小于无焦虑患者。患者术前焦虑评分与LOC所需时间和丙泊酚Ce均显著负相关,Pearson相关系数分别为-0.4和-0.7。结论患者术前焦虑状态与丙泊酚诱导过程中患者意识消失的速度相关。焦虑患者更易入睡。

Objective It is to evaluate the correlation between preoperative anxiety score and time to loss of consciousness （LOC） or the effect site concentration of propofol at LOC. Methods Patients scheduled for elective gynecologic surgeries un- der general anesthesia were included. Anxiety score was assessed before surgery. Propofol was given by target controlled infu- sion with a target plasma concentration of 4 mg/L for induction. The time to patients showing no response to loud verbal in- struction （LOC） and the effect site concentration of propofol at LOC were recorded. Pearson analysis was used to determine the correlation between anxiety scores and the two induction parameters. Results Patients of moderate or severe anxiety need shorter duration and lower Ce of propofol to LOC. The score of anxiety was significantly negatively correlated to both the time to LOC and the Ce of propofol at LOC, with Pearson coefficient of - 0.4 and - 0.7 respectively. Conclusion The anxiety sta- tus is related to the time to LOC during propofol induction. The more anxious the patient is, the faster he falls into asleep.