摘要
目的探讨脐带间充质干细胞移植联合负压封闭引流术(VSD)治疗Ⅲ、Ⅳ期压疮的临床效果。方法Ⅲ、Ⅳ期压疮患者143例随机分为3组。对照组30例行常规换药治疗,实验一组58例应用脐带间充质干细胞移植联合VSD治疗,实验二组55例仅应用VSD治疗。比较3组患者愈合时间及愈合效果。结果实验一组和实验二组的显效时间和愈合时间均较对照组显著缩短(P均<0.05),且实验一组较实验二组更短(P均<0.05)。实验一组的治愈率显著高于对照组(P<0.05),与实验二组比较无显著性差异,实验二组的治愈率与对照组比较无显著性差异。实验一组的总有效率显著高于对照组和实验二组(P均<0.05),实验二组与对照组比较无显著性差异。结论脐带间充质干细胞移植联合VSD较单用VSD及常规治疗方法均能更好地改善Ⅲ、Ⅳ期压疮创面的愈合,避免组织感染,提高压疮患者的生活质量。
Objective It is to investigate the clinical efficacy of umbilical cord mesenchymal stem cell transplantation com- bined with VSD therapy in the treatment of stage Ⅲ and Ⅳ bedsore. Methods 143 cases with stage Ⅲ and Ⅳ bedsore were selected and randomly divided into the control group, experimental group 1 and 2. 30 cases in the control group were given conventional treatment, 58 cases in the experimental group 1 were treated by umbilical cord mesenchymal stem cell transplan- tation combined with VSD treatment, while 55 cases in the experimental group 2 were treated by VSD treatment alone. The healing time and healing effect were compared among the three groups after treatment. Results The effect initiating time and healing time of experimental group 1 and 2 were significantly shortener than that of the control group(P 〈 0.05) , which was more shorter in the experimental group 1 than that in the experimental group 2. The recovery rate of experiment group I was significantly higher than that of the control group(P 〈 0.05) , but no significant difference was found between the experiment group 1 and 2 as well as the experiment group 2 and control group. The total effective rates of experimental group 1 was signifi- cantly higher than those of the experimental group 2 and control group, while no significant difference was found between ex- periment group 2 and the control group. Conclusion Umbilical cord mesenchymal stem cell transplantation combined with VSD therapy could more effectively accelerate the wound healing of bedsore, avoid tissue infection, improve the quality of life of pa- tients with pressure ulcers than the treatment of epidermal growth factor alone and conventional treatment.
出处
《现代中西医结合杂志》
CAS
2013年第28期3085-3086,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
压疮
脐带间充质干细胞移植
负压封闭引流术
pressure sores
umbilical cord mesenchymal stem celt transplantation
vacuum sealing drainage