“芪蛭胶囊”对脑梗死患者同型半胱氨酸和血清超敏C反应蛋白的影响

Influence of QIZHI capsule on serum levels of homocysteine and hs-CRP in patients with cerebral infarction

目的探讨芪蛭胶囊对脑梗死患者同型半胱氨酸(Hcy)和血清超敏C反应蛋白(hs-CRP)的影响。方法 68例脑梗死患者随机分为2组,对照组予常规治疗,治疗组加用芪蛭胶囊口服,21 d为1个疗程,测定患者Hcy、hs-CRP治疗前后的变化,以NIHSS表评价神经缺损功能。结果治疗后2组Hcy水平均有明显下降(P均<0.05),但治疗组降低幅度更大(P<0.05);2组治疗后hs-CRP评分与治疗前比较均无显著性差异(P均>0.05);2组NIHSS水平与治疗前比较均有显著性差异(P<0.01),但组间比较无显著性差异(P>0.05)。结论芪蛭胶囊能降低脑梗死患者的Hcy水平,发挥脑保护作用。

Objective It is to approach the influence of QIZHI capsule on serum levels of homocysteine （Hcy） and hs- CRP in patients with cerebral infarction. Methods 68 patients with cerebral infarction were divided into two groups. The pa- tients were treated with normal treatments in control group and with combination of normal treatments and QIZHI capsule in tri- al group. The levels of Hey and hs -CRP were measured, and the score of National Institutes of health stroke scale （NIHSS） was also assessed. Results The levels of Hcy in both groups were markedly decreased after treatment （ all P 〈 0.05）, and those were more lower in treated group. There were no significant changes in hs - CRP levels after treatment in both groups （ all P 〉 0.05）. There were significant difference in NIHSS after treatment compared with before （ P 〈 0.05 ）, but there were no significant difference between both groups （P 〉 0.05 ）. Conclusion QIZI-II capsule can decrease the serum levels of I-Icy in patients with Cerebral infarction, and may protect brain tissues.