摘要
目的探讨尿酸(UA)与缺血性脑卒中后认知功能障碍的相关性。方法根据蒙特利尔认知评估(MoCA)进行认知功能评分,83例脑梗死患者分为有认知功能障碍(A组,43例)和无认知功能障碍(B组,40例)两组,检测血浆UA、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)水平。结果 A组UA水平高于B组(P<0.05)。Spearson相关分析显示,UA与MoCA评分呈负相关(r=-0.509,P<0.05)。多因素Logistic回归分析显示,UA是缺血性脑卒中后认知功能障碍的独立危险因素。结论血浆UA与MoCA评分密切相关,UA在缺血性脑卒中后认知障碍的发生及发展过程中可能起重要作用。
Objective To explore the correlation between plasma uric acid（UA） and cognitive impairment after stroke. Methods On the basis of Montreal cognitive assessment（MoCA） ,83 patients with ischemic stroke were divided into two groups of A（40 cases with cognitive impairment） and B（43 cases without cognitive impairment）. Serum levels of uric acid （UA）, high density of lipoprotein cholesterol（HDL-C）, low density of lipoprotein cholesterol （LDL-C） and triglyceride （TG） were deermined and compared. Results Serum UA was significantly higher in group A than that in group B （P〈0. 05）. Spearson correlation analysis showed that UA was negatively correlated to MoCA score （r=-0. 509,P〈0. 05）. Logistic regression analysis showed that UA level was an independent risk factor for cognitive impairment after ischemic stroke. Conclusion UA is closely related to MoCA score and may play an important role in cognitive impairment after ischemic stroke.
出处
《江苏医药》
CAS
北大核心
2013年第18期2161-2163,共3页
Jiangsu Medical Journal
