序贯疗法与四联疗法根除幽门螺杆菌疗效观察

Observation of Curative Effect on Eradication of Helicobactor Pylori with Quadruple Therapy and Sequential Therapy

目的:比较传统四联疗法与序贯疗法根除幽门螺杆菌(Hp)临床疗效及安全性。方法:选取本院86例2012年8月～2013年2月14C尿素呼气试验阳性或胃镜活检胃粘膜组织快速尿素酶检查阳性病例,随机分为两组,A组:口服奥美拉唑20mg1日2次,胶体果胶铋150mg1日4次,阿莫西林胶囊1000mg1日2次,克拉霉素500mg1日2次,治疗7d;B组:前5d口服奥美拉唑20mg1日2次,阿莫西林胶囊1000mg1日2次,后5d口服奥美拉唑20mg1日2次,克拉霉素胶囊500mg1日2次,替硝唑500mg1日2次;停药四周后复查14C尿素呼气试验检测,阴性者为根除。结果:传统四联疗法治疗7d,根除幽门螺杆菌有效率为83.7%,序贯疗法根除幽门螺杆菌有效率为95.3%.差异有显著性(P<0.05)。结论:序贯疗法明显优于四联疗法,值得临床推广。

objective： To compare the traditional quadruple therapy with sequential therapy the eradication of he- lieobacter pylori （Hp） clinical efficacy and safety. Methods Select our hospital 86 cases of August 2012, 2013 - February 14 e urea breath test positive or gastroscope biopsy of gastric mucosal tissue rapid urease tests positive cases, were randomly divided into two groups： group A： oral omeprazole 20 mg twice A day, colloidal bismuth pectin 150 mg four times A day, 1000 mg amoxicillin capsule twice A day, clarithromycin 500 mg twice A day, 7 days of treatment; 5 days before the group B： oral omeprazole 20 mg twice a day, 1000 mg amoxicillin capsule twice a day, five days after the oral omeprazole 20 mg twice a day, 500 mg elarithromycin capsule twice a day, 500 mg twice a day for indications; Discontinuation after review around 14 e urea breath test to detect, was for eradication. Results Traditional quadruple therapy for 7 days, the eradication of helieobacter pylori effective rate was 83.2%, sequential therapy, the eradication of helicobacter pylori effective rate was 95.3%. There are significant difference （P 〈 0.05）. Conclusion Sequential therapy is superior to quadruple therapy, worth clinical promotion.