江西省靖安县农村妇女高危型人乳头状瘤病毒感染的横断面研究

High-risk human papillomavirus infection among rural women of Jing'an County in Jiangxi Province: a cross-sectional study

目的：调查江西省靖安县农村女性子宫颈上皮内高危型人乳头状瘤病毒（high—riskhumanpapillomavirus，hr—HPV）的感染状况。方法：2012年5月至2012年11月在江西省靖安县地区对35～59岁女性进行人群横断面调查，纳入研究的4673例受检者中2491例采用了杂交捕获法（HC-2）方法检测hr—HPV，另外2182例采用凯普医用核酸分子快速导流杂交基因芯片技术进行hr—HPV检测并分型。结果：hr—HPV感染率为11．9％，混合感染占41．5％。在进行了分型的2182例中HPV52型感染率最高（2．8％），其次分别是58、16和39型。hr—HPV感染率在靖安县山区和平原地区之间无差异，年龄分布则有显著性差异（P〈0．001）。结论：江西省靖安县农村女性hr—HPV感染率与我国其他地区近似，HPV52和58型是该地区优势感染型，hr—HPV感染防治策略应针对不同地域人群的特点有所不同。

Objective： To investigate ttae prevatenccwas conducted among rural the rural women of ling-an County in Jiangxi Province. Methods： A population-based cross-sectional study women of ages 35 years to 59 years in ling-an County between May 2012 and November 2012. A total of 4 673 women were enrolled. Hybrid capture2 （hc2） was detected in 2 491 women, whereas HybriMax was detected in 2 182 women to understand the different hr-HPV types. Results： The overall hr-HPV prevalence was 11.9%. Multiple-type infections accounted for 41.5%. The most commonly seen hr-HPV type was HPV52 （2.8%）, followed by HPV58, HPV16, and HPV39. No significant difference was observed in the preva lence of hr-HPV infection between women in the mountainous and the plain areas in ling-an County. However, the age distribution of HPV infection significantly differed （P〈0.001）. Conclusion： Hr-HPV infection rate in ling-an County was close to that of other areas in China. HPV52 and HPV58 appeared to be the most prevalent HPV types and should be employed as a basis for HPV prevention in this area.