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微小RNA在内皮细胞参与的血管生成中的作用 被引量：4

MicroRNA regulation of angiogenesis in endothelial cells
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摘要 微小RNA是真核生物中一类长度约22个核苷酸的小分子非编码RNA,它通过与靶基因的3UTR结合,抑制靶基因翻译或使其降解,实现对靶mRNA转录后水平的调控。微小RNA参与生物体内许多复杂的生理过程,与细胞增殖、分化、凋亡、胚胎发育、血管生成、组织器官形成以及多种疾病的发生发展密切相关。最近的研究表明,微小RNA在内皮细胞参与的血管生成中发挥重要的调控作用,本文将就近年来微小RNA在血管生成调控方面的研究做一综述。 Summary MicroRNAs are the class of small. 22-nucleotides long non-coding RNA in eukaryotes. MicroR- NAs typically control the expression of their target genes in post-transcriptional level for promoting either their degradation or translational repression by imperfect pairing to the 3＇ untranslated regions. MicroRNAs are involved in the control of a wide range of biological functions including cell development, differentiation, apopto- sis, embryonic development, angiogenesis, tissue and organ formation and development of a lot of diseases. It is increasing evidence that miRNAs play important roles in angiogcnesis in endothelial cells. In this review, we aim at describing the role of miRNAs in angiogenesis.
作者 钟华 陆瑶 缪汝佳 袁洪
机构地区 中南大学湘雅三医院心内科 中南大学湘雅三医院临床药理研究中心
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2013年第9期650-653,共4页 Journal of Clinical Cardiology
基金 重大疾病治疗药物药理学研究(No:2011CB512001) 重大疾病新药临床评价研究综合技术平台建设(No:2012ZX09303014001) 老年人群治疗风险及策略的临床转化医学技术研究(No:2012BA137B05)
关键词 MICRORNA 内皮细胞 血管生成 microRNA endolhelial cell angiogenesis
分类号 Q522 [生物学—生物化学]
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参考文献20

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共引文献12

同被引文献30

  • 1Vishalakshi Chavali,Suresh C. Tyagi,Paras Kumar Mishra.Differential Expression of Dicer, miRNAs, and Inflammatory Markers in Diabetic Ins2+/? Akita Hearts[J].Cell Biochemistry and Biophysics.2014(1)
  • 2S. Vigili de Kreutzenberg,A. Avogaro.The limited clinical value of a specific diabetic cardiomyopathy[J].Nutrition Metabolism and Cardiovascular Diseases.2013(7)
  • 3Paras Mishra,Tyagi,Chavali.Predictors and prevention of diabetic cardiomyopathy[J].Diabetes Metabolic Syndrome and Obesity: Targets and Therapy (default).2013(default)
  • 4Rajesh Katare,Andrea Caporali,Lorena Zentilin,Elisa Avolio,Graciela Sala-Newby,Atsuhiko Oikawa,Daniela Cesselli,Antonio Paolo Beltrami,Mauro Giacca,Costanza Emanueli,Paolo Madeddu.Intravenous Gene Therapy With PIM-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling[J].Circulation Research.2011(10)
  • 5Basel Khraiwesh,M. Asif Arif,Gotelinde I. Seumel,Stephan Ossowski,Detlef Weigel,Ralf Reski,Wolfgang Frank.Transcriptional Control of Gene Expression by MicroRNAs[J].Cell.2010(1)
  • 6Rabih Murr.Interplay Between Different Epigenetic Modifications and Mechanisms[J].Advances in Genetics.2010
  • 7Reena V. Kartha,Subbaya Subramanian.MicroRNAs in Cardiovascular Diseases: Biology and Potential Clinical Applications[J].Journal of Cardiovascular Translational Research.2010(3)
  • 8BiaoFeng,ShaliChen,BijuGeorge,QingpingFeng,SubrataChakrabarti.miR133a regulates cardiomyocyte hypertrophy in diabetes[J].Diabetes Metab Res Rev.2010(1)
  • 9Rudy F. Duisters,Anke J. Tijsen,Blanche Schroen,Joost J. Leenders,Viola Lentink,Ingeborg van der Made,Veronica Herias,Rick E. van Leeuwen,Mark W. Schellings,Paul Barenbrug,Jos G. Maessen,Stephane Heymans,Yigal M. Pinto,Esther E. Creemers.miR-133 and miR-30 Regulate Connective Tissue Growth Factor: Implications for a Role of MicroRNAs in Myocardial Matrix Remodeling[J].Circulation Research.2009(2)
  • 10杨汆,丁志坚,朱傲霜,刘小宇,马玲娣,王芳芳.冠心病患者血浆periostin蛋白与血管内皮生长因子的相关性[J].中国动脉硬化杂志,2011,19(2):135-138. 被引量：11

引证文献4

二级引证文献10

临床心血管病杂志
2013年 第9期

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