2型糖尿病患者血清血管生成因子浓度的变化

Changes in serum concentrations of angiogenic factors in patients with type 2 diabetes mellitus

选取42例2型糖尿病患者（DM组）、23例糖尿病合并不稳定型心绞痛患者（DM＋UAP组）和36名正常健康者（对照组）。收集血清，然后使用蛋白芯片检测血清中血管内皮生长因子（VEGF）、血管形成蛋白（Ang）-1、Ang-2、血管生成素、血管抑制素、碱性成纤维细胞生长因子和血小板源性生长因子BB浓度。结果显示，DM组与对照组比较，所有7个因子的血清浓度差异均无统计学意义，而DM＋UAP组Ang-2和VEGF水平较对照组显著增高[（3532．10±1813．72对2444．50±1152．21）pg／ml，（286．90±217．01对171．92±106．63）pg／ml，均P〈0．01]。7个血管生成因子浓度与HbA1、空腹血糖、餐后2h血糖、甘油三酯、高密度脂蛋白胆同醇和低密度脂蛋白胆同醇均无显著相关。

Forty-two patients with type 2 diabetes （ DM group）, 23 type 2 diabetic patients with unstable angina pectoris （ DM ＋ UAP group ）, and 36 healthy subjects （ control group ） were enrolled in this study. Serum samples were collected for determining serum concentrations of vascular endothelial growth factor （ VEGF ） , Angiopoietin （Ang）-1, Ang-2, angiogenin, angiostatin, basic fibroblast growth factor, and platelet-derived growth factor-BB using protein array technology. The results showed that there were no significant differences in serum concentrations of all 7 angiogenic factors between control group and DM group. Whereas, serum concentrations of VEGF and Ang-2 were significantly increased in DM＋UAP group compared with control group [ （3 532.10 ± 1 813.72 vs 2 444.50 ± 1 152.21 ） pg/ml, （ 286.90 ± 217.01 vs 171.92 ± 106.63 ） pg/ml, both P〈0.01 ]. Pearson＇s con＇elation analysis revealed that serum concentrations of all 7 angiogenic factors were not related to HbA1c, fasting and 2 h postprandial plasma glucose, triglycerides, high density lipoprotein cholesterol, as well as low density lipoprotein cholesterol.