摘要
目的筛选并优化了和厚朴酚自微乳化给药系统(honokiol-SMEDDS)的处方。方法利用溶解度,辅料配伍实验及伪三元相图筛选空白处方,以粒径和体外释放评价为指标选取最佳处方。结果优化后的honokiol-SMEDDS处方油相为辛癸酸甘油酯(MCT),表面活性剂为聚氧乙烯氢化蓖麻油(Cremophor RH40),助表面活性剂为二乙二醇单乙基醚(Transcutol P),油相比例20%,表面活性剂与助表面活性剂的比值K m为2,载药量为10%,平均粒径为28 nm。结论成功制备了honokiol-SMEDDS,显著提高了和厚朴酚的溶解度。
Objective To screen and optimize the formulation of self-microemulsifying drug delivery system (SMEDDS) for honokiol. Methods The formulation of honokiol-SMEDDS was screened by solubility experiment, compatibility test for excipients and pseudo-ternary phase diagrams. And the best formulation was determined by the particle size and in vitro release evaluation. Results In the best formulation of honokiol- SMEDDS, octyl and decyl glycerate (MCT), polyoxyethylene hydrogenated castor oil (Cremophor RH40) and diethylene glycol monoethyl ether (Transcutol P) were used as oil phase, surfactant and co-surfactant, respec- tively. The percentage of oil phase was 20%, Km of surfactant to cosurfactant was 2, the drug loading was 10%, and the average particle size was 28 nm. Conclusion The honokiol-SMEDDS is prepared successfully, and the solubility of honokiol is improved significantly.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2013年第19期2073-2076,共4页
Journal of Third Military Medical University
基金
重庆市自然科学基金(CSTC2012jjA10021)
高等学校博士学科点专项科研基金(20125503120003)
重庆医科大学大学生科研与创新实验项目(201244,201229,201217)~~
关键词
和厚朴酚
自微乳化给药系统
伪三元相图
honokiol
self-microemulsifying drug delivery system
pseudo-ternary phase diagram