喜炎平注射液与10种药物配伍稳定性考察

Compatibility of Xiyanping injection with ten selected drugs

目的考察喜炎平注射液分别与10种药物配伍后在5%葡萄糖注射液或氯化钠注射液中的稳定性。方法将喜炎平注射液分别与注射用青霉素钠、硫酸阿米卡星注射液、硫酸庆大霉素注射液、甲磺酸酚妥拉明注射液、注射用头孢噻肟钠、克林霉素磷酸酯注射液、氢化可的松注射液、注射用美洛西林钠、注射用头孢拉定、葡萄糖酸钙注射液10种药物配伍,考察配伍后6 h内药液的性状、pH值、不溶性微粒、主要成分磺化物E含量的变化情况。结果配伍药液的外观颜色在6 h内无显著变化;注射用青霉素钠与喜炎平注射液配伍后的pH值在6 h内逐渐下降,其他药物配伍后pH值无显著变化;喜炎平注射液与10种药物配伍后不溶性微粒数量明显增多,且均超出中国药典规定;配伍药液的主要成分磺化物E含量在6 h内无显著变化。结论喜炎平注射液在临床上可用5%葡萄糖注射液或氯化钠注射液稀释静脉滴注,严禁与上述10种药物在同一容器内混合使用。

AIM To investigate the compatibility of Xiyanping injection with ten different drugs in 5% glucose injection or sodium chloride injection. METHODS Xiyanping injection was mixed with ten different drugs, such as benzylpenicillin sodium for injection, amikacin sulfate injection, gentamycin sulfate injection, phentolamine mesilate injection, cefotaxime sodium for injection, clindamycin phosphate injection, hydrocortisone injection, mezlocillin sodium for injection, cefradine for injection, calcium gluconate injection in 5% glucose injection or sodium chloride injection, respectively. The color, clarity, pH value, insoluble particles and main ingredients of the mixtures were determined. RESULTS There were no changes in the color within 6 hours. The pH values of benzylpenicillin sodium for injection were reduced gradually within 6 hours,while no significant changes were examined in the other mixtures. The insoluble particles were detected in Xiyanping injection mixed with ten drugs, and they didn＇ t reach the pharmacopoeia standards. There were no changes in content of sulfonate E within 6 hours. CONCLUSION Xiyanping injection is compatible with 5% glucose injection or sodium chloride injection within 6 hours, and incompatible with the above ten drugs.