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膜蛋白UBIAD1在生物医学中的功能研究进展

Research Progress on the Function of Transmembrane Protein UBI- AD1
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摘要 Ubiadl是一个重要的人体代谢与疾病基因。UBIADl蛋白能治疗人体恶性肿瘤、心血管疾病、帕金森氏疾病及施耐德眼角膜综合症。同时，UBIADl影响人体脂代谢，维生素代谢以及辅酶Q代谢，其研究具有重大的生物医学意义。由于UBIADl蛋白在人体不同类型的细胞中，处于不同的亚细胞定位，执行不同的生物学功能。研究UBIADl的亚细胞定位及其存各人体疾病中的生理功能之间的对应关系，目前已成为国际上研究UBIADl的焦点。系统回顾UBIADl蛋白在人体各种疾病中的分子机制，及在各生理病理过程中的亚细胞定位及功能，为进一步研究UBIADI的分子机制及用UBIADl来治疗人体疾病奠定基础。 Ubiadl is an important human metabolic and disease gene. UBIADI protein is in- volved in cancer, cardiovascular disease, parkinson＇ s disease and schnyder corneal dystrophy. In the normal physiological condition, UBIADi participates in human lipid metabolism, vitamin K synthesis as well as CoQ10 synthesis. Study of UBIAD1 has profound impact and significance in bio- medical research. Therefore, understanding the molecular mechanism of UBIAD1 is vital in curing various human diseases. Meanwhile, since UBIAD1 protein has different subcellular localization and thus exert different biological function in different human cell types. Studying the relationship be- tween UBIAD1 subcellular localization and its corresponding physiological function has currently be- come the focal point of the international UBIAD1 research community, summarize the recent progress in UBIADI research, explore the molecular mechanism of UBIAD1 in various human diseases as well as its subcellular localization and corresponding function in various physiological and pathophys- iological conditions so that a solid foundation can be laid down to further the study of the molecular mechanism of UBIAD1 and the potential therapeutic application of UBIAD1.
作者 夏炎枝 红凌
机构地区 分子生物物理教育部重点实验室
出处 《医学分子生物学杂志》 CAS 2013年第4期220-225,共6页 Journal of Medical Molecular Biology
基金 资助项目：国家自然科学基金（No.81272210,30971608）,武汉市国际科技合作项目（No.201070934334）
关键词 UBIAD1 异戊稀转移酶 癌症 心血管疾病 神经退行性疾病 UBIAD1 prenyltransferase cancer cardiovascular disease, neurodegenerative disease
分类号 R73 [医药卫生—肿瘤]
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参考文献30

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二级参考文献23

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医学分子生物学杂志
2013年 第4期

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