含青刺果及马齿苋的医学护肤品对湿疹屏障修复作用的观察

Restoring effect of a skin care product containing Prinsepla utilis Royle and purslane on skin barrier function in patients with chronic eczema

目的观察含马齿苋及青刺果提取物的医学护肤品恢复慢性湿疹患者皮肤屏障功能。方法选取慢性湿疹患者80例，其中男46例，女34例。用自身对照试验，治疗侧使用含青刺果及马齿苋的医学护肤品及糠酸莫米松乳膏，对照侧单独使用糠酸莫米松乳膏，1周后双侧停用糠酸莫米松乳膏，但治疗侧继续使用使用含青刺果及马齿苋的医学护肤品，于第0天、7天、30天、60天进行随访，通过皮肤油脂含量、角质层含水量及经表皮水分流失量（TEWL）来评估皮肤屏障功能，于第60天观察患者症状和皮损改善情况评估疗效及复发率。结果第60天，80例患者治疗侧使用医学护肤品后症状和体征改善的有效率较对照侧显著升高（P〈0．01）；复发率较对照侧显著降低（P〈0．01）。第0天、7天、30天、60天治疗侧皮脂含量、角质层含水量较治疗前及对照侧升高，TEWL值较治疗前及对照侧降低，差异有统计学意义（P〈0．01），随着治疗时间延长，皮肤油脂含量、角质层含水量及TEWL值逐渐恢复正常。结论用含青刺果及马齿苋的医学护肤品可恢复慢性湿疹皮肤屏障功能，降低复发率。

Objective To evaluate the restoring effect of a skin care product containing Prinsepia utilis Royle and purslane on skin barrier function in patients with chronic eczema. Methods Eighty patients with chronic eczema, including 46 males and 34 females, were recruited in this study. A self-controlled study was performed. Lesions on one body side of the patients （experiment side） were topically treated with a skin care product containing Prinsepia utilis Royle and purslane in combination with mometasone furoate cream once daily, and those on the other body side （control side） treated with mometasone furoate cream alone once daily. Mometasone furoate cream was applied for one week in both sides, and the skin care product for 60 days in the experiment side. Patients visited the hospital on day 0, 7, 30 and 60 after the beginning of treatment. Skin harrier function was evaluated by skin sebum content, stratum corneum hydration and transepidermal water loss （TEWL）. The improvement of signs and symptoms was estimated in patients at the end of the treatment （on day 60）. Results At the end of the 60-day treatment, the experiment side showed significantly higher response rate hut lower recurrence rate compared with the control side （all P 〈 0.01）. Moreover, skin sebum content and stratum corneum hydration significantly increased, hut TEWL value statistically decreased in the experiment side on day 7, 30 and 60 compared with those in the same side on day 0 as well as those in the control side at these same time points （all P 〈 0.01 ）. After the start of treatment, skin sebum content, stratum corneum hydration and TEWL value gradually restored to the normal levels over time in the experiment side. Conclusion The skin care product containing Prinsepia utilis Royle and purslane can effectively restore skin barrier function in, and decrease the recurrence of, eczema.