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抑制性寡核苷酸对矽尘所致肺泡炎的机制及应用

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摘要 免疫抑制性寡核苷酸（suppressive oligodeoxynucleotides,Sup ODN）是人工合成的具有特定核苷酸顺序的单链DNA分子.实验证实,富含＂TTAGGG＂基序的Sup ODN和哺乳动物端粒DNA具有下调Th1型细胞因子及前炎症介质产生的作用[1].我们就其可能对矽尘所致肺泡炎的作用机制和应用进行综述.
作者 雷鹏 宋富军 王世鑫
机构地区 四川省南充市蓬安县人民医院检验科 天津市西青医院 天津市滨海新区大港卫生防病站
出处 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2013年第9期719-720,共2页 Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词 免疫抑制性 寡核苷酸 肺泡炎 矽尘 TH1型细胞因子 DNA分子 核苷酸顺序 前炎症介质
分类号 R135.2 [医药卫生—劳动卫生]
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参考文献14

  • 1Lkeuchi H,Kinjo T,Klinman DM.Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas.Cancer Prev Res(Phila),2011,4:752-757.
  • 2Krieg Am,Wu T,Weeratna R,et al.Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs.Proc Natl Acad Sci,1998,95:12631-12636.
  • 3Gursel I,Gursel M,Yamada H,et al.Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation.J Immunol,2003,171:1393-1400.
  • 4Trieu A,Roberts TL,Dunn JA,et al.DNA Motifs Suppressing TLR9 Responses.Crit Rev Immunol,2006,26:527-544.
  • 5Wang YZ,Lian QH,Ramkalawan H,et al.Inactivation of TLR9 by a suppressive oligodeoxynucleotides can ameliorate the clinical signs of EA N.Immunol Invest,2012,41:171-182.
  • 6Klinman DM,Zeuner R,Yamada H,et al.Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides.Ann N Y Acad Sci,2003,1002:112-123.
  • 7Gursel I,Gursel M,Yamada H,et al.Repetitive elements in mammalian telomeres malian suppress bacterial DNA-induced immune activation.J Immunol,2003,171:1393-1400.
  • 8Shirota H,Gursel MK,linman DM.Suppressive Oligodeoxynucleotides inhibit Thl differentiation by blocking IFN-γand IL-12-mediated signaling.J Immunol,2005,173:5002-5007.
  • 9Shirota H,Gursel I,Gursel M,et al.Suppressive Oligodeoxynucleotides protect mice from lethal endotoxic shock.J Immunol,2005,174:4579-4583.
  • 10Klinman DM,Tross D,Klaschik S,et al.Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides.Ann N Y Acad Sci,2009,1175:80-88.

二级参考文献29

  • 1Hamilton RF Jr, Thakur SA, Holian A. Silica binding and toxicity in alveolar macrophages. Free Radic Biol Med, 2008, 44: 1246-1258.
  • 2Geiser M. Update on macrophage clearance of inhaled micro- and nanoparticles. J Aerosol Med Pulm Drug Deliv, 2010, 23: 207-217.
  • 3Gilberti RM, Joshi GN, Knecht DA. The Phagocytosis of crystalline silica particles by macrophages. Am J Respir Cell Mol Biol, 2008, 39: 619-627.
  • 4Scarfi S, Magnone M, Ferraris C, et al. Ascorbic acid pre-treated quartz stimulates TNF-c~ release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxi- dation. Respir Res, 2009, 186: 465-992.
  • 5Thakur SA, Beamer CA, Migliaccio CT, et al.Critical role of MARCO in crystalline silica-induced puhnonary Inflammation. Toxicological Sciences, 2009, 108: 462-471.
  • 6Zhou H, Imrich A, Kobzik L, et al. Characterization of immortalized MARCO and SR-AI/II-defieient murine alveolar macrophage cell lines. Part Fibre Toxieol, 2008, 5: 7.
  • 7Hibbs JB.Infection and nitric oxide. J Infect Dis, 2002, 185: S9-17.
  • 8Gordon S. Ahernative activation of macrophages. Nat Rev Immunol, 2003, 3: 23-35.
  • 9Miqliaccio CT, Buford MC, Jessop F, et al. The IL-4Ra pathway in macrophages and its potential role in silica-induced pulmonary fi- brosis. J Leukoc Biol, 2008, 83: 630-639.
  • 10Misson P, van den Brule S, Barbarin V, et al. Markers of macrophage differentiation in experimental silicosis. J Leukoe Biol, 2004, 76: 926-932.

共引文献19

中华劳动卫生职业病杂志
2013年 第9期

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