摘要
介绍一种合成左氧氟沙星的新工艺。以(2,3,4,5)-四氟苯甲酰氯为起始原料,与3-乙氧基丙烯酸乙酯反应,然后L-氨基丙醇进行胺化反应,环合、水解后与N-甲基哌嗪缩合制得左氧氟沙星,总收率为50.15%。该工艺操作简单,环境污染小,符合绿色化学发展方向,值得进一步研究和推广。
New process for preparing Levofloxacin was described. The target was prepared from （2,3,4,5 ）- fluorobenzoic chloride, which reacted with ethyl 3-ethoxyacrylate, amination with S-（＋ ）-2-aminopropanol, cyclization ,hydrolysis and condensation with N-methyl piperazine. The total yield was 50.15%. The process has many advantages, such as simple operation, less environmental pollution. In line with the green chemistry development direction, it deserves further research and popularization.
出处
《浙江化工》
CAS
2013年第9期13-15,22,共4页
Zhejiang Chemical Industry
