猪饥饿和喂饲后内服氟甲砜霉素的药动学比较

The Comparative Pharmacokinetics of Florfenicol After Oral Administration to Fasted and Fed Pigs

报道了猪饥饿及喂饲后 5min单剂量 (2 0mg/kg)内服氟甲砜霉素的药动学比较的研究 .用高效液相色谱法测定血药浓度 .试验所得的血浆浓度 时间数据采用非房室模型统计矩原理分析处理 .猪饥饿后内服给药的主要药物动力学参数 :AUC =(91 40± 7 5 1)mg·h/L ,MRT =(7 15± 0 5 8)h ,t1/ 2 β=(5 99± 0 2 6 )h .猪喂饲后 5min内服给药的主要药物动力学参数为 :AUC =(88 47± 2 2 1)mg·h/L ,MRT =(10 94± 1 0 6 )h ,t1/ 2 β=(6 44± 0 90 )h .试验结果表明 ,猪喂饲后内服氟甲砜霉素的生物利用度与饥饿后的相似 ,但峰浓度显著小于饥饿后的峰浓度 ,两者的消除半衰期相似 .

The comparative pharmacokinetics of florfenicol was investigated after oral administration to fed and fasted pigs at a dosage of 20 mg/kg. The plasma concentrations of florfenicol were determined by HPLC with UV detection at 223 nm. Plasma concentration time data derived from the experiment were analyzed by non compartmental methods based on statistical moment theory. The pharmacokinetic parameters of florfenicol following oral administration after a 16 h fast were as follows: AUC =(91.40±7.51) mg·h/L, MRT =(7.15±0.58) h,β=(0.13±0.01)h -1 , t 1/2β =(5.99± 0.26) h. The main pharmacokinetic parameters following administration of florfenicol orally 5 min post feeding were as follows: AUC = (88.47±2.21) mg·h/L, MRT =(10.94±1.06) h,β=(0.12±0.02) h -1 , t 1/2β =(6.44±0.90) h. The result show that bioavailabilities after oral administration were similar in both fasted and fed pigs. However, the peak concentration was significantly less in fed pigs than that in fasted pigs. The half life of the elimination was similar in fasted and fed pigs.