尿酸盐转运蛋白在原发性痛风及高尿酸血症中的研究进展

Study Overview of Urate Transporter Proteins in Primary Gout and Hyperuricemia

原发性痛风及高尿酸血症是临床常见病、多发病,主要病因是尿酸盐转运蛋白异常致尿酸排泄减少。近年来,尿酸转运蛋白成为进行抗高尿酸血症和痛风药物的研究和开发新靶点,是目前防治痛风的新思路和新方法。简要概述尿酸盐转运蛋白在原发性痛风及高尿酸血症中的研究现状,以供原发性痛风及高尿酸血症的进一步临床诊治研究及特异性靶点药物研发参考。

Primary gout and hyperuricemia are frequently- occurring and common diseases ; the main cause is urate transporter protein abnormalities which can lead to decrease in uric acid excretion. In recent years, the urate transporter proteins become the new target for drug research and development of anti hyperuricemia and gout, and are new ideas and new ways to combat gout. This article briefly outlines the urate transporter proteins with primary gout and hyperuricemia. Research offers the reference for further clinical diagnosis and treatment of primary gout and hyperuricemia and specific targets for drug development.