空气消毒剂复方香艾液急性毒性实验研究

Experimental Study on Acute Toxicology of Air Disinfectant Liquid Compound Xiang'ai Aerosol

目的:研究空气消毒剂复方香艾液使用的安全性,采用动物试验方法进行毒理学安全性评价。方法:SPF级KM小鼠急性吸入毒性实验、新西兰兔多次完整皮肤刺激实验、多次破损皮肤刺激实验、急性眼刺激实验等观察动物局部和全身有无异常变化。结果:本研究中昆明种雌、雄小鼠的急性经呼吸道吸入毒性实验,一般生理体征未见异常,血常规、血清生化指标无异常,脏器组织病理学检查未见明显异常,LC50均大于10000 mg/m3,属实际无毒级;对新西兰家兔的多次完整皮肤刺激实验、多次破损皮肤刺激实验、急性眼刺激实验均属无刺激性。结论:复方香艾液空气消毒剂属实际无毒级空气消毒液。

Objective：It is to study the safety of compound Xiang＇ai Aerosol, and to conduct toxicological assessment through animal test. Methods ： Acute respiratory toxicity tests at the KM mice ; more times completed skin rritation, more times damaged skin irritation, and acute eye stimulating with observations in New Zealand rabbits, and then the results were observed. Results：In this study, for male KM mice acute toxicity inhalation through respiratory tract test, routine blood and biochemical examination had no abnormal change; organization pathological examination showed no abnormal chan- ges;LCs0 were greater than 10000 mg/m3 , belonging to the actual non - toxic level. The more times completed skin irrita- tion, more times damaged skin irritation, and acute eye stimulation tests for New Zealand rabbits were all nonirritant. Conclusion：The Compound Xiang＇ai Aerosol is actually nontoxic disinfectant.