不同给药方式下鲤对诺氟沙星的药代动力学研究

Study on pharmacokinetics of Norfloxacin in carp following different forms administration

通过不同给药方式鲤对诺氟沙星的药代动力学研究，建立相关的吸收、分布与消除等药动学参数及生物 利用度资料。结果以 １０ｍｇ·ｋｇ－１鱼体重单剂量肌注、口灌诺氟沙星的药时数据符合开放性二室模型，以 １０ｍｇ· ｋｇ－１鱼体重药物剂量单次混饲给药的药时数据符合开放性一室模型。肌注给药的主要药代动力学参数为：ＡＵＣ２４．９４８１μｇ·ｈ·ｍＬ－１， Ｃｍａｘ １６．８９９２μｇ·ｍＬ－１，ｔ１／２α０．１２７９ｈ，ｔ１／２β ３．４０３２ｈ；口灌给药的主要药代动力学参数为：ＡＵＣ１５０．６０２９μｇ·ｈ·ｍＬ－１，Ｃｍａｘ５．７９９８μｇ·ｍＬ－１，ｔ１／２α３．４０７１ｈ，ｔ１／２β７７．１２３９ｈ；混饲口灌给药的主要药代动力学 参数为： ＡＵＣ６．８１８３μｇ·ｈ·ｍＬ－１，Ｃｍａｘ１．７２１７μｇ·ｍＬ－１，ｔ１／２ｋａ０．２２６４３ｈ，ｔ１／２ｋｅ２．０２１３ｈ。不同给药方式的主要药 代动力学参数差异显著（Ｐ＜０．０１）。

Several pharmacokinetics relative datas such as absorption, distribution, elimination and bioavailability have been set up in this study on pharmacokinetics of Norfloxacin in carp following different forms administration. Following single muscular injection and oral administration, the serum concentration the data of Norfloxacin in carp were best described by a two-compartment open model for dose of 10 mg Norfloxacin /kg body weight. Following single mixed in diet oral administration, the serum concentration-time data for Norfloxacin were best described as a one-compartment open model. The main pharmacokinetics parameters by muscular injection administration: AUC 24.9481 μg·h·mL-1, Cmaxl6.8992 μg·mL- 1, t1/2α 0. 1279 h, t1/2β 3.4032 h. The main pharmacokinetics prameters by orally administration: AUC 150.6029 μg·h·mL-l, Cmax5.7998 μg·mL-l, t1/2α3.407lh, t1/2β77. 1239h. The chief pharmacokinetics parameters by mixed in diet oral administered: AUC 6.8183 μg·h·mL- l, Cmax1 .7217μg·mL- l, t1/2ka 0.22643h,t1/2ke 2.0213h. The results showed that the main parameters following different forms administration were significantly different (P < 0.01).