多种脂肪细胞因子与脑梗死患者颈动脉粥样硬化斑块稳定性的关系

Relationship between adipocytokine cagetory and the stability of carotid plaque in patients with acute cerebral infarction

目的探讨多种脂肪细胞因子与急性脑梗死(ACI)患者颈动脉粥样硬化斑块稳定性的关系。方法根据颈动脉彩色多普勒超声仪检查结果,将113例ACI患者分为无斑块组、稳定斑块组和不稳定斑块组;采取酶联免疫法检测ACI患者发病<48h和14d时以及31名健康对照者的血清脂联素、抵抗素、内脏脂肪素、白介素-6(LI-6)和白介素-8(LI-8)的水平。结果 (1)ACI患者发病<48h和14d时血清内脏脂肪素、抵抗素、LI-6、LI-8水平明显高于对照组,脂联素水平明显低于对照组。与发病<48h相比,ACI患者发病14d时血清内脏脂肪素、抵抗素、LI-6、LI-8水平明显升高,脂联素水平明显降低。(2)不稳定斑块组血清内脏脂肪素、抵抗素、LI-6、LI-8水平高于稳定斑块组和无斑块组,脂联素水平明显低于稳定斑块组和无斑块组。(3)血清内脏脂肪素、抵抗素、LI-6、LI-8水平与颈动脉斑块不稳定性呈正相关,而血清脂联素水平与颈动脉斑块不稳定性呈负相关。结论血清脂肪细胞因子内脏脂肪素、抵抗素、LI-6、LI-8水平升高和脂联素水平降低与脑梗死患者颈动脉粥样硬化斑块的不稳定显著相关,有望成为评价斑块稳定性及预测脑梗死发生的理想生化指标。

Objective To explore the relationship between adipocytokine cagetory and the stability of carotid plaque in patients with acute cerebral infarction（ACI）.Methods According to the result of carotid ultrasonographic,113 patients with acute cerebral infarction were recruited into three subgroups： Group NCP（no carotid plaques）,Group SP（stable plaque）,Group VP（vulnerable plaques）.The serum levels of adiponectin,resistin,visfatin,IL-6 and IL-8 in all patients（48 hours and 14days after ACI） and 31 healthy persons were measured by means of ELISA,and then to analysis the association of these indexes.Results（1） The serum levels of resistin,visfatin,IL-6 and IL-8 on 48 hours and 14days after ACI were significantly higher than that in the healthy controls,but adiponectin was opposite.（2） The serum levels of resistin,visfatin,IL-6 and IL-8 in Group VP were significantly higher than that in Group SP and Group NCP,but adiponectin was opposite.（3） The serum adopinectin levels in the patients with ACI and unstability of carotid plaque in Patients with ACI were negative correlation,but the serum resistin,visfatin,IL-6 and IL-8 levels in the patients with ACI and unstability of carotid plaque in patients with ACI were positive correlation.Conclusion The serum adiponectin,resistin,visfatin,IL-6 and IL-8 levels are significantly correlation to unstability of carotid plaque in patients with ACI.And these adipocytokine may be biochemical indicator for estimating stability of carotid plaque and prediction ACI.