丁酸梭菌的研究应用进展

Progress on the Studies and Application of Clostridium butyricum

丁酸梭菌是从健康人和动物肠道中分离出的一种厌氧的革兰氏阳性芽孢杆菌,因其能够产生芽孢的益生功能被广泛的研究。丁酸梭菌作为新一代芽孢益生菌制剂,较非芽胞益生菌制剂具有耐热、耐酸和耐多种抗生素等生物学特性,能对宿主产生各种健康作用。如调节肠道微生态平衡、稳定胃肠道功能、产生益生物质、提高机体免疫及促进动物生长等,具有更好的应用发展前景。主要对丁酸梭菌的生物学功能、发酵工艺及其在临床与动物饲料中的应用研究进展进行综述,并展望丁酸梭菌今后的研究方向。

Clostridium butyricum,as a probiotic has been studied widely,is a spore-forming,gram-positive anaerobe that is found in intestines of healthy animals and humans.As a novel spore-forming probiotic,C.butyricumcan withstand the low pH,heat and many antibiotic compared with non-spore forming probiotics,and exert different health effects in host,such as regulation of intestinal microbial homeostasis,stabilization of the gastrointestinal barrier function,enzymatic activity inducing absorption and nutrition,immunomodulatory effects,improvement of the animal production performance.So it will be used more widely.In this paper,we reviewed advances in the biological function,the fermentation technology and the application in clinic and feed additive ofC.butyricum.Some advices were also put forward for further research of C.butyricum.