长托宁对急性有机磷中毒患者心肌损伤的临床疗效

Intervention of penehyclidine hydrochloride on myocardial injury in acute organophosphate poisoning patients

目的:探讨长托宁对急性有机磷中毒患者心肌损伤的临床疗效。方法:应用随机数字表法将85例有机磷中毒患者随机分为对照组41例和治疗组44例,对照组给予阿托品,治疗组使用长托宁进行治疗;用药结束后对患者心肌酶α-HBDH、CK、CK-MB、AST、LDH的活性,及血清TNF-α、IL-6和IL-8进行评价,记录患者的不良反应发生率和住院时间。结果:治疗后治疗组的心肌酶α-HBDH、CK、CK-MB、AST和LDH活性下降,与对照组有明显差异(P<0.05);治疗组血清中TNF-α、IL-6和IL-8水平低于对照组,有显著差异(P<0.05);治疗组的不良反应发生率和住院时间也少于对照组,差异有统计学意义(P<0.05)。结论:长托宁对急性有机磷中毒患者的心肌损伤具有一定的改善作用,能够有效降低有机磷中毒患者的炎症因子,提高急救效果,且该药不良反应少,值得临床上广泛推广。

OBJECTIVE To observe the effects of enehyclidine hydrochloride in acute organophosphate poisoning complicated with myocardial injury. METHODS 85 Patients were randomly divided into observation group （44 cases） and control group （41 cases） by method of randomized digital table. The control group was treated by atropine, and the observation group was treat by penehyclidine hydrochloride. C The curative effects were evaluated by enzyme activity of a-HBDH, CK, CK-MB, AST and LDH, level of TNF-a,IL6 and IL8 in serum, recording the adverse reaction rate and length of hospitalized days. RESULTS a-HBDH, CK, CK - MB, AST and LDH of the observation group decreased, and observation group were different from that of the control group significantly（P〈0. 05）. TNF-a, IL-6 and IL-8 in serum of observation group lower than those of the control group, there were significant differences （P〈0. 05）. The adverse drug reaction rate and length of hospital stay were less than control group, too（P〈0. 05）. CONCLUSION Penehyclidine hydrochloride combined with routine therapies has less adverse drug reaction, and obvious efficiency on increasing the success rate of acute organophosphorus pesticide poisoning patients complicated with myocardial injury.