复方苦参注射液治疗恶性胸腔积液疗效观察

Effect of compound matrine injection on malignant pleural effusion

目的:观察复方苦参注射液胸腔内注射治疗恶性胸腔积液的疗效、生活质量和不良反应。方法:将80例恶性胸腔积液患者分为治疗组和对照组(n=40),进行胸腔穿刺及中心静脉置管引流管排尽胸水后,治疗组胸腔内每次注射复方苦参注射液40 mg,对照组胸腔内每次注射顺铂40 mg·m-2,每周1次,4次为1疗程。1疗程后观察疗效、生活质量和不良反应。结果:治疗组有效率62.5%,缓解率67.5%;对照组的有效率65%,缓解率65%;两组比较无统计学差异。治疗组不良反应发生率明显低于对照组(P<0.05)。结论:复方苦参注射液胸腔内注射治疗恶性胸腔积液疗效好,可改善患者生活质量,不良反应少,患者易耐受,依从性好,值得临床推广应用。

Objective： To observe the efficacy,the quality of life and adverse effects of compound matrine injection by intrathoracic injection in the treatment of malignant pleural effusion.Methods： This study included 80 patients with malignant pleural effusion,pleural puncture and central venous catheter drainage tube after thoracic water draining.Patients were treated with either intrathoracic injection of compound matrine 40 mg or cisplatin 40 mg·m-2（control）,once a week,a total of 4 times for 1 course of treatment.Curative effect,the quality of life and side effects were observed after 1 course of treatment.Results： The rates of effective response and the quality of life were 62.5% and 67.5% in matrine group,and 65% and 65% in control group,respectively.No statistical difference was found between two groups.Side effects was significantly lower in matrine group than in control group（P 0.05）.Conclusion： Compound matrine injection is effective in the treatment of malignant pleural effusion,and can improve the quality of life and reduce side effects.Thus,it has better tolerance and compliance,and is worthy of clinical application.