左旋肉碱在多囊卵巢综合征发病机制中的作用

Role of L-Carnitine in pathogenesis of polycystic ovary syndrome

目的：研究左旋肉碱在多囊卵巢综合征（PCOS）发病机制中的作用.方法：选择2010年2月～2012年2月在本妇产科门诊就诊的PCOS患者30例为观察组,同期因男性不育及输卵管因素就诊的月经周期正常不孕妇女30例作为对照组,采用高效液相色谱法检测观察对象的左旋肉碱水平,酶联免疫吸附测定法检测瘦素（LP）水平,化学发光法检测生殖激素水平,并分析它们之间的相关性.结果：PCOS组左旋肉碱水平低于对照组（P＜0.05）,而LP、黄体生成激素（LH）、LH/卵泡刺激素（FSH）和睾酮（T）水平高于对照组（P＜0.05）,且左旋肉碱与T和Lp均呈负相关（r=-0.421,P＜0.05；r=-0.526,P＜0.05）.结论：左旋肉碱可能参与PCOS的发生发展.

Objective：To explore the function of L-Carnitine in pathogenesis of polycystic ovary syndrome （PCOS）.Methods：Thirty women seeking for PCOS treatment and 30 infertility women for male factors or abnormal oviduct served as the study group and the control group,respectively.The level of serum L-Carnitine was tested by high performance liquid chromatography.And the levels of serum leptin and hormone were evaluated by ELISA and chemical luminescence method,respectively.The correlations of parameters mentioned above were analyzed.Results：The levels of L-Carnitine,leptin,luteinizing Hormone （LH）,the ratio of LH to follicle-stimulating hormone （FSH） and testosterone （T） in PCOS patients were significantly higher than those of the control group.There were negative correlations between the level of L-Camitine and the levels of T （r =-0.421,P ＜ 0.05） and leptin （r =-0.526,P ＜ 0.05）,respectively.Conclusion：L-Carnitine may play an important role in occurrence and development of PCOS.