进展性脑梗死患者血清IL-1β、IL-6水平研究

Study on the Levels of Serum Interleukin-1β and Interleukin-6 in Patients with Progressive Cerebral Infarction

目的分析进展性脑梗死(PCI)患者血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平,探讨其可能的发病机制。方法 66例脑梗死患者根据入院后病情进展情况分为进展组和非进展组,各33例;根据梗死体积分为小梗死组、中梗死组、大梗死组,各22例。另选取健康体检人员40例为对照组。清晨空腹时取静脉血5mL,取血清,ELISA法检测IL-1β、IL-6水平。结果非进展组和进展组患者血清IL-1β、IL-6水平均明显高于对照组;进展组血清IL-1β、IL-6水平明显高于非进展组。中、大梗死组患者血清IL-1β、IL-6水平明显高于小梗死组,大梗死组患者血清IL-1β、IL-6水平明显高于中梗死组。大梗死组PCI发生率明显高于小梗死组。结论脑梗死患者血清IL-1β、IL-6水平与梗死体积有关,且对PCI发生具有早期预警意义。

Objective To analyze the levels of serum interleukin-1β （IL-1β） and interleukin-6 （IL-6） in patients with progressive cerebral infarction and explore its possible pathogenesis. Methods Sixty-six patients with cerebral infarction were divided into progressive group and non-progressive group according to pathological progression after admission into hospital, 33 cases in each group. They were divided into small, middle and large infarction groups, 22 cases in each group. Meanwhile, 40 healthy people were selected as control group. 5 mL of venous blood from each fasting patient was drawn in the morning. Enzyme-linked immunosorbent assay （ELISA） was used to detect the levels of IL-1β and IL-6. Results The levels of serum IL-1β and IL-6 in progressive and non- progressive groups were significantly higher than that in control group, and those in progressive group obviously higher than non-progressive group. The levels of serum IL-1β and IL-6 in middle and large infarction groups were significantly higher than that in small infarction group, and those in large infarction group obviously higher than middle infarction group. The incidence of percutaneous coronary intervention （PCI） in large infarction group was notably higher than that in small infarction group. Conclusion The levels of serum IL-1β and IL-6 in patients with cerebral infarction are associated with infarction volume, and have an early warning significance for the occurrence of progressive cerebral infarction.