蛋白SUMO化修饰与疾病关联性的研究进展

Relationship between protein sumoylation modification and disease

类泛素化修饰蛋白(small ubiquitin-related modifier,SUMO)是一类重要的类泛素蛋白,SUMO化修饰对底物蛋白功能的发挥起着重要的调节作用。SUMO化修饰的异常与人类许多重大疾病密切相关,如肿瘤、神经退行性病变、脑损伤、糖尿病以及家族性扩张型心肌病等。

The small ubiquitin-related modifier（SUMO） is an important member of the small ubiquitin like protein（Ubl） family.Sumoylation of proteins is an important regulatory element in mediating protein function.It has been shown that dysregulation of sumoylation is implicated in pathogenesis of human diseases such as cancers,neurodegenerative diseases,brain injuries,diabetes and familial dilated cardiomyopathy.