摘要
目的比较国产盐酸万古霉素(来可信)与进口盐酸万古霉素(稳可信)对于中性粒细胞缺乏合并感染的儿童恶性肿瘤的临床疗效。方法选择于化疗后出现中性粒细胞缺乏合并感染的恶性肿瘤患儿100例随机分成2组,来可信组53例,稳可信组47例,对两组的细菌清除率、临床疗效及不良反应进行比较。结果来可信组治愈率64.2%,总有效率92.5%;稳可信组治愈率61.7%,总有效率93.6%,两组比较差异均无统计学意义(P>0.05)。来可信组及稳可信组的总不良反应发生率分别为11.3%及12.8%,两组比较差异无统计学意义(P>0.05)。结论对于化疗后合并中性粒细胞缺乏及感染的儿童血液肿瘤患者,国产与进口万古霉素治愈率、有效率、不良反应发生率相当,疗效肯定,安全性好。
Objective To compare the clinical efficacy and safety of domestic and imported vancomycin hydrochloride (laikexin and vancocin) for the treatment of infection in children with agranulocytosis.Methods 100patients with malignant diseases and agranulocytosis were randomly divided into two groups.53 patients were given laikexin,and 47 patients were given vancocin.The efficacy and safety of the two groups was observed.Results In laikexin group,the curative rate was 64.2%,effective rate was 92.5%,adverse effect rate was 11.3% ;in vancocin group they were 61.7%,93.6% and 12.8%.No significant difference was found between the two groups(P > 0.05).Conclusion There is no significant difference in clinical efficacy and safety between domestic vancomycin group and imported vancomycin group.Both of them are effective and safe for the treatment of infection in malignant diseases children with agranulocytosis.
出处
《实用药物与临床》
CAS
2013年第8期696-698,共3页
Practical Pharmacy and Clinical Remedies