组织工程血管化策略的研究进展

Research Progress of Vascularization in Tissue Engineering

体内、外构建组织工程化组织的主要障碍都在于缺少足够的血液供应,也就是血管化问题。组织工程血管化的策略目前主要分为两类。第一类是基于内皮细胞等去构建新的血管,在这个过程中生长因子也有促进新生血管的作用。第二类是基于支架技术,包括天然生物衍生的支架和人工合成支架。本文就组织工程血管化策略的研究进展进行综述。

Nowadays the main problem in tissue engineering both in vitro and in vivo is the lack of sufficient blood supply - the vascularization. There are two main current strategies to create vascularized tissues. The first strategy is based on the cells and their ability to form new vessels. In this process growth factors as well as cells are contribute to generate new vessels. The second strategy is scaffold based techniques, including naturally -derived scaffolds and synthetically manufactured scaffolds. Future strategies to create vascularized tissues were reviewed.