奥氮平治疗36例老年痴呆患者临床疗效分析

Analysis of the Efficacy of Olanzapine in the Treatment of 36 Cases of Elderly Patients with Dementia

目的探讨奥氮平治疗老年痴呆患者的临床疗效。方法 72例老年痴呆患者,随机分成对照组和观察组。对照组给予利培酮治疗。观察组给予奥氮平治疗。结果治疗2、4、6周后,两组PANSS量表评分均明显优于治疗前,差异有统计学意义(P<0.01);治疗2、4、6周后,观察组PANSS量表评分优于对照组,差异有统计学意义(P<0.05)。结论奥氮平治疗老年痴呆疗效佳,建议临床推广应用。

Objective To investigate the clinical efficacy of olanzapine in the treatment of patients with senile dementia.Methods 72 cases of senile dementia patients were randomly divided into control group and observation group.The control group was given risperidone and the observation group was treated with olanzapine.Results 2,4,6 weeks after treatment,PANSS scale scores of the two groups were significantly better than those before treatment,the differences were statistically significant（P〈0.01）.2,4,6 weeks after treatment,the PANSS scale scores of the observation group were better than those of the control group and the differences were statistically significant（P〈0.05）.Conclusion Olanzapine has good curative effect on senile dementia,which is worthy of clinical application.