卡维地洛对急性心肌梗死伴糖尿病患者再灌注治疗后左心功能的影响

目的 评价卡维地洛对急性心肌梗死伴糖尿病患者溶栓后左心功能的影响.方法 以64例急性心肌梗死伴糖尿病静脉溶栓后的患者为研究对象,随机分为卡维地洛组和对照组各32例,所有患者均接受静脉溶栓及常规治疗.卡维地洛组在对照组用药基础上服用卡维地洛,总疗程4周.对两组患者治疗前后有关心功能、血糖等指标进行比较.结果 卡维地洛组治疗后左室舒张末期内径、左室收缩末期内径均减小（P＜0.01）,左心室射血分数及心输出量,短轴缩短率均有提高（P＜0.01）,血糖、甘油三脂、总胆固醇均有降低（P＜0.05或P＜0.01）.对照组仅见LVEF、FS有统计学意义（P＜0.05）.结论 卡维地洛治疗心肌梗死伴糖尿病患者,对改善心功能优于对照组,同时能改善血糖血脂代谢.

Aims To evaluate the effects of carvedilol on left ventricular function in acute myocardial infarction （AMI） patients with diabetes after thrombolysis.Methods Sixty-four patients with AMI and diabetes treated by carvedilol were divided into control group （n=32） and carvedllol group （n=32） who were received carvedilol for four weeks randomly. All patients were received thrombolysis and routine treatments. The parameters of left ventricular function and blood sugar levels were compared between the two groups. Results The left ventricular end diastolic diameter, left ventricular end systolic diameter, blood sugar levels, blood triglycerides levels were significantly lower and left ventricular ejection fraction （LVEF）, cardiac output were significantly higher in carvedilol group after four weeks treatments than those with control group. However, LVEF and fraction shortening were improvement after four weeks treatment in control group only.Conclusions Carvedilol is effective in improve the left ventricular function and metabolism of blood sugar and fat in AMI patients with diabetes.