摘要
目的 探讨高压氧对溃疡性结肠炎患者的临床疗效及血清肿瘤坏死因子-α （TNF-α）、白介素-6（IL-6）的影响.方法 选择94例溃疡性结肠炎患者,随机分为柳氮磺胺吡啶组（对照组,46例）和高压氧联合柳氮磺胺吡啶组（治疗组,48例）.治疗4周后,观察患者的临床症状、结肠镜下黏膜改变以及治疗前后血清TNF-α和IL-6水平的变化.结果 4周后,治疗组临床症状改善和结肠镜下黏膜炎症修复情况优于对照组[（总有效率分别为（89.6％、71.7％）、（89.6％、73.9％）]（P＜0.05）、血清TNF-α和IL-6水平治疗组明显低于对照组[分别为（25.7±6.9、35.2±7.5）ng/L和（12.6 ±2.8、22.8±5.4）ng/L]（P＜0.05）.结论 高压氧能明显改善溃疡性结肠炎患者的临床症状和黏膜炎症；降低血清TNF-α和IL-6水平.
Objective To observe the therapeutic effects of hyperbaric oxygen and its effects on the serum levels of TNF-α and IL-6 in patiebts with ulcerative colitis.Methods A total of 94 ulcerative colitis papients randomly classified into sulfasalazine group （control group,n=46） and group with hyperbaric oxygen combination sullasalazine（therapy group,n = 48）. Clinical symptoms, endoscopical findlngs,TNF-α and IL-6 levels in sera were evaluated 4 weeks after treatment.Results Compared with those of group with hyperbaric oxygen combination sulfasalazine,clinical symptom（89.6% vs71.7%） and colonic mucosal inflammation （89. 6%vs73.9%）in sulfasalazine group was significantly in proved （p〈0.05）.and serum levels of TNF-α and IL-6 also markedly decreased[（25.7 ± 6.9, 35.2 ± 7.5）ng/L vs（12.6± 2.8. 22.8 ±5.4）ng/L] （p〈0.05）.Conclusion Hyperbaric oxygen is effective to treat ulcerative colitis and down-regulate TNF-α and IL-6 secretion.
