真空间歇精馏提纯天然烟碱

Purification of Natural Nicotine by Vacuum Batch Distillation

针对提取天然烟碱传统工艺中粗烟碱精制过程烟碱损失量大及烟碱产品纯度不够高的问题,采用真空间歇精馏方法对烟碱粗产品进行了精制,并确定了适宜的操作条件。该过程包含如下两阶段:溶剂回收阶段,塔顶压力50～100 kPa,回流比2～4,溶剂收率为88.7%;烟碱精制阶段,塔顶压力不超过0.5 kPa,回流比3～5,烟碱质量分数和收率分别到达99.5%和74.0%以上。此方法操作稳定可靠,便于控制,易于实现工业化。

Because of big loss and low purity of product in traditional refining process for extraction of natural nicotine,an innovative method for purification of nicotine by vacuum batch distillation was studied.And the suitable operating conditions were obtained.The distillation process included two stages as follows： In solvent recovery stage,the appropriate pressure was 50—100 kPa and reflux ratio was 2—4,respectively,and the recovery of chloroform was 88.7%.While in nicotine refining stage,the suitable operating pressure was not more than 0.5 kPa,the reflux ratio was 3—5.And the purity（mass fraction） and yield of nicotine was more than 99.5% and 74.0%,respectively.The method to refine nicotine is steady,convenient for control and easy to be realized in industrialization.