摘要
目的对比布加综合征（BCS）和肝内型门静脉高压症（IPH）患者手术前后肝脏组织病理学变化的特征。方法所有18例（BCS者10例，IPH者8例）资料在治疗后半年时间时穿刺抽取肝脏组织，测定肝脏Ⅲ型前胶原、Ⅳ型胶原和TIMP-1的表迭特点，通过HE染色法研究肝组织形态，另外在手术治疗过程中测量FPP情况并分析其与肝脏的纤维化程度的相关性。结果BCS患者的肝脏Ⅲ型前胶原与Ⅳ型胶原、TIMP-1的数据与治疗前相比出现显著性下降（P〈0．05），FPP值明显降低（P〈0．05）；IPH患者治疗前后的Ⅲ型前胶原、Ⅳ型胶原和TIMP-1统计指标无明显变化（P〉0．05），FPP值明显降低。结论BCS通过治疗缓解了梗阻，使患者肝脏病理性特点可逆性改变；IPH治疗后压力得到一定程度改善但肝脏病理性特点未显著性改变。
Objective To analysis Budd--Chiari syndrome and intrahepatic portal hypertension patients before and after liver histopathological changes characteristic. Methods All 18 cases （BCS 10 cases, IPH 8 cases） information in the six months after treatment time puncture liver tissue, the liver was measured procollagen type Ⅲ, IV collagen and TIMP-1 expression characterized by HE staining study of liver tissue morphology. Results BCS patients with liver type Ⅲ procollagen type Ⅳ collagen, TIMP-1, compared with before treatment data appear significantly decreased （P〈0. 05）, FPP significantly reduced. Conclusion BCS alleviated through treatment obstruction, the patient characteristics of reversible liver pathological changes.
