摘要
以水杨酸为原料,采用浓硝酸/冰醋酸作为硝化剂,合成5-硝基水杨酸;再用铁粉还原制得抗结肠炎药美沙拉嗪.合成路线简便,操作简单,设备腐蚀较小,反应条件温和,收率较高,适合工业化生产.
5 - nitrosalicylic acid was synthesized using salicylic acid as raw material and nitric acid / glacial acetic acid as nitrating agent. Then, the Mesalazine was prepared by reduction. The method is characterized with simple route, easy operation, less corrosion, moderate reaction condition and high yield. It is suitable for industrial production.
出处
《重庆文理学院学报（社会科学版）》
2013年第5期73-75,共3页
Journal of Chongqing University of Arts and Sciences（Social Sciences Edition)
基金
重庆市自然科学基金资助项目(CSTC2012JJA10153)
重庆文理学院重点项目(Z2012CH18)
重庆文理学院学生科研项目(XY20110073
XY20120011)
关键词
抗结肠炎
水杨酸
5-硝基水杨酸
美沙拉嗪
anti - colitis
salicylic acid
5 - nitrosalicylic acid
Mesalazine
