左乙拉西坦添加治疗婴儿痉挛症的对照研究

Efficaly of domestic Levetiracetam add-on therapy for West syndrome

目的探讨左乙拉西坦(Lev)治疗婴儿痉挛症(west syndrome,WS)的临床疗效和安全性。方法将符合诊断标准的癫痫儿童30例随机均分为两组,治疗组在丙戊酸钠治疗的基础上添加左乙拉西坦治疗,对照组予丙戊酸钠单药治疗,治疗12周。比较两组治疗的疗效与不良反应。结果治疗组有效率为60%(9/15),对照组有效率为26.7%(4/15),两组有效率比较有显著性差异(P<0.05);对照组不良反应发生率13.3%(2/15),较治疗组20%(3/15)不良反应少,但两者相比差异无显著性(P>0.05)。结论左乙拉西坦(Lev)治疗婴儿痉挛疗效好,不良反应少。

Objective To evaluate the efficacy,safety and to lerability of domestic Levetiracetam as therapy in patients with West syndrome.Methods 30 children with West syndrome were randomly devided into two groups.Therapy group took Levetiracetam,control group took Volproic acid.The clinical effect,change of EEG and adverse reaction were observed after twelve weeks.Results There were significant differences in the good initial responses between two groups,which were 60% and 26.7%,respectively（P0.05）.The incidence of Levetiracetam therapy related adverse effects in the therapy group（20%） was not significantly higher than in the control group（13.3%）（P0.05）.Conclusion Levetiracetam is effective,safe and well tolerated in patients with West syndrome.