期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

α3β1整合素与肾小球足细胞脱落的研究进展 被引量：3

下载PDF
导出
摘要 肾小球是肾脏滤过单位,其滤过功能与滤过屏障密切相关.肾小球滤过屏障可有效阻止白蛋白等大分子量物质进入尿液,其结构和功能的改变是蛋白尿产生的病理生理基础.肾小球滤过屏障由内而外分为三层：①首先是带窗孔的肾小球内皮细胞;②其次为肾小球基底膜（GBM）,这是一高度水化的胶原网,对白蛋白及其他血浆大分子物质兼有分子及电荷屏障作用,GBM含有紧密交联的层黏连蛋白（LN）、Ⅳ型胶原（Ⅳ-collagen）、纤维连接蛋白（FN）和硫酸乙酰肝素蛋白多糖（HSPG）,GBM中主要的HSPG是集聚蛋白（agrin）,这些HSPG构成GBM的高度阴电荷;③足突（FP）及覆盖于FP裂隙间的裂孔隔膜（SD）.足细胞作为肾小球滤过膜的重要组成部分,在维持肾小球正常滤过方面具有至关重要的作用.足细胞从GBM上脱落会导致肾小球滤过屏障的完整性遭到破坏.足细胞通过许多分子锚定于GBM上,如：α3β1整合素、αβ蛋白聚糖复合体（αβdystroglycan complex）、辅肌动蛋白（α-actinin）、组织蛋白酶-L（cathepsin-L）、尿激酶纤维蛋白酶原激活剂受体（UPAR）、磷酸二酯酶抑制剂（B7-1）等[1～5],其中α3β1整合素与足细胞脱落之间的关系最近成为研究热点.本文就α3β1整合素与足细胞脱落的相互关系作一综述.
作者 赵辉 赵伟 袁莉 贾莉 王卫华 李琳
机构地区 菏泽医学高等专科学校 菏泽市立医院
出处 《山东医药》 CAS 2013年第36期95-98,共4页 Shandong Medical Journal
关键词 α3β1整合素 足细胞 足细胞脱落 蛋白尿
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献26

  • 1Reiser J, von Gersdorff G, Loos M, et al. Induction of B7-1 in podocyte is associated with nephrotic syndrome [ J ]. J Clin Invest, 2004,113 (10) : 1390-1397.
  • 2Reiser J, Oh J, Shirato I. Podocyte migration during nephrotic syn- drome requires a coordinated interplay between cathepsin L and al- pha3 integrin[ J]. J Biol Chem, 2004,279(33) :34827-34832.
  • 3Kojima K, Davidovits A, Poczewski H, et al. Podocyte flattening and disorder of glomerular basement membrane are associated with splitting of dystroglycan-matrix interaction [ J ]. Am Soc Nephrol, 2004,15 ( 8 ) :2079 -2089.
  • 4Danapani SV, Sugimoto H, Matthews BD, et al. ct-Actinin-4 is re- quired for normal podocyte adhesion[J]. J Biol Chem, 2007,282 ( 1 ) :467-477.
  • 5Marshall, Sally M The Podocyte: a potential therapeutic target in diabetic nephropathy [ J ]. Cart Pharm Des, 2007, 13 ( 26 ) : 2713-2720.
  • 6Yu JS, Christman KL, Chin E, et al. Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin [ J ]. PLoS One, 2009,4 (8) : e6721.
  • 7Economou C, Kitsiou P, Tzinia A, et al. Enhanced podocalyxin expression alters the structure of podocyte basal surface [ J ]. J Cell Sci, 2004,117(15) :3281-3294.
  • 8Pozzi A, Jarad G, Moeckel GW, et al. Betal integrin expression by podocytes is required to maintain glomerular structural integrity [J]. Dev Biol, 2008,316(2) :288-301.
  • 9Zanone MM, Favaro E, Doublier S, et al. Expression of nephrin by human pancreatic islet endot belial cells [ J J. Diabetologia, 2005,48 (9) :1789-1797.
  • 10Chen CA, Tsai JC, Su PW, et al. Signaling and regulatory mecha- nisms of integrin a31l on the apoptosis of cultured rat podocytes[J]. Lab Clin Med, 2006,147(6):274-280.

二级参考文献14

  • 1[1]STEFFES M W,SCHMIDT D,MCCRERY R,et al.Glomerular cell number in normal subjects and in type1 diabetic patients[J].Kidney Int,2001,59:2104-2113.
  • 2[2]CHEN H C,CHEN C A,GUH J Y,et al.Alteing expression of alpha3 beta1 integrin on podocytes of human and rats with diabetes[J].Life Sci,2000,67:2345-2353.
  • 3[3]MUNDEL P,SHANKLAND S J.Podocyte biology and response to injury[J].J.Am Soc Nephrol,2002,13:3005.
  • 4[4]KIM Y H,GOYAL M,KURNIT D,et al.Podocytedepletion and Glomerulosclerosis have a direct relationship in the PAN-treated rat[J].Kidney Int,2001,60:957-968.
  • 5[5]SHANKLAND S J.The podocyte's response to injury:role in proteinuria and glomerulosclerosis[J].Kidney Int.2006,69 (12):2131-47.
  • 6[7]SIU B,SAHA J,SMOYER W E,et al.Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents:prevention by lipoic acid treatment[J].BMC Nephrol,2006;7:6.
  • 7[8]SMOYER W E.Podocyte alpha-actinin induction precedes foot process effacement in experimental nephrotic syndrome[J].Am J Physiol Renal Physiol,1997,273:150.
  • 8[9]KRETZLER M.Regulation of adhesive interaction between podocytes and glomerular basement membrane[J].Microsc Res Tech,2002,57 (4):247-253.
  • 9[10]REGOLI M,BENDAYAN M.Alterations in the expression of the alpha3 beta1 integrin in certain membrane domains of the glomerular epithetlial cells (podocytes) in diabetes mellitus[J].Diabetologia,1997,40:15-22.
  • 10[11]KREIDBERG J A,DONOVAN M J,GOLDSTEIN S L,et al.Alpha 3 beta1 integrin has a crucial role in kidney and lung organogenesis[J].Development,1996,122:3537-3547.

共引文献5

同被引文献16

引证文献3

二级引证文献7

山东医药
2013年 第36期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部