血清特异性IgE检测在慢性鼻-鼻窦炎中的作用

Serum special IgE and total IgE detection in chronic rhinosinusitis

目的研究血清特异性IgE(sIgE)和总IgE(tIgE)检测对于慢性鼻-鼻窦炎的临床意义。方法 2009年2月-2010年1月在我科治疗的112例慢性鼻-鼻窦炎患者,采用MAST过敏原检测系统检测35种变应原的sIgE以及tIgE,同时记录慢性鼻-鼻窦炎的分型、合并哮喘、LundLund内镜评分、Lund-Mackay CT评分等客观情况。结果 tIgE阳性率为50.89%,sIgE阳性率为14.29%。tIgE阳性组和tIgE阴性组在客观检查方面无明显差别。而sIgE阳性组较sIgE阴性组的内镜评分更高、哮喘发生率更高。结论对于慢性鼻-鼻窦炎患者,tIgE检测意义不大,而sIgE可提示该疾病严重程度,并能提示临床医师注意观察下呼吸道的情况。

Objective To investigate the clinical role of serum special IgE （sIgE） and total IgE （ttgE） in chronic rhinosinusitis. Methods One hundred and twelve patients from Feb. 2009 to Jan. 2010 were studied. MAST sys- tem for allergy was used to detect 35 kinds of sIgE and tIgE. The type of chronic rhinosinusitis, asthma happening, endoscopic scores and CT scores were also recorded. Results There were 57 patients with positive tIgE （50.89%） , and there were 16 cases with sIgE - positive（14.29% ）. On the type of chronic rhinosinusitis, com- pany with asthma, endoscopic score and CT score, there were no significant difference between tIgE - positive group and tIgE - negative group, sIgE - positive group had higher prevalence rate of asthma and was more severe due to endoscopic scores than sIgE - negtive group （ P 〈 0.05 ）. Conclusion There is no necessary for chronic rhinosi- nusitis to detect tIgE. While sIgE detection is necessary for the patients with chronic rhinosinusitis, because it can reflect the degree of chronic rhinosinusitis and has tips on the accompanied disease of lower respiratory tract.