斑秃患儿甲状腺功能及血中微量元素分析

Analysis of thyroid hormone function and trace elements in children with alopecia areata

目的研究斑秃患儿甲状腺功能及微量元素与斑秃发病的关系。方法采用贝克曼化学发光免疫分析仪DXI800测定血清甲状腺激素水平;同时运用原子吸收光谱仪BH2101S和BH5100对152名斑秃患儿和321名体检健康儿童进行全血铜、锌、钙、镁、铁、铅等微量元素的测定比较。结果斑秃患儿总三碘甲腺原氨酸和游离三碘甲腺原氨酸均高于正常对照组,且其全血锌、全血钙水平显著低于健康对照儿童,全血铅水平显著高于健康对照组。结论斑秃患儿发病可能与甲状腺功能损害,锌、钙缺乏或铅中毒有关。对斑秃患者应及时检查甲状腺功能及其微量元素含量,早期对症治疗。

Objective To study the relationship between incidence of alopecia areata and thyroid hormone levels as well as human blood trace elements in children. Methods Serum thyroid hormone levels were determined by Beckerman chemiluminescence immunoassay analyzer DXI800, and at the same time, the human blood trace ele- ments （copper, zinc, calcium, magnesium, iron, lead）of 152 alopecia areata patients and 321 healthy controls were determined by atomic absorption spectrometer BH2101S and BH5100. Results The total triiodothyronine and free triiodothyronine levels of the children with alopecia were significantly higher than those of control group. The whole blood zinc and calcium level of the children with alopecia areata were significantly lower than those of healthy controls, while the blood lead level in the patients with alopecia areata was significantly higher than that in healthy controls. Conclusion The incidence of alopecia areata may be concerned with the thyroid functional lesion, the lack of zinc, calcium and lead poisoning. So timely detection of thyroid function and the whole blood trace elements in the children with alopecia areata is beneficial for early symptomatic treatment.