浅析中医治疗克罗恩病与溃疡性结肠炎的用药特点

Analysis of Characteristics of Medicine of TCM Treatment for Crohn's Disease and Ulcerative Colitis

目的探索中医治疗克罗恩病（Crohng＇sdisease，CD）与溃疡性结肠炎（Ulcerative colitis，UC）的用药异同。方法收集1994—2012年治疗CD复方52首，录入“中药复方分析”软件，对其药类、核心药物、药对进行统计分析；将其与已总结之256首治UC的用药特点比较。结摹（1）治CD与UC所使用中药中居前9位的药类相同，共居前4位的依次为补虚、清热、理气、渗湿药，居5～9位，前者为活血、解表、温里、收涩、止血药，后者为收涩、温里、解表、活血、止血药。（2）居前10位的核心药物，治疗CD为甘草、白术、白芍、党参、当归、黄连、茯苓、陈皮、薏苡仁、木香，治疗UC为甘草、白术、党参、木香、黄连、白芍、茯苓、黄芪、当归、陈皮；常用药对是核心药物的排列组合。结论研究表明，CD与UC同属于炎症性肠病，中医治疗该病的遣药组方思路基本一致，即配补气健脾、清热燥湿、利水渗湿、温里祛寒药以消除病因，配理气导滞、活血化瘀、祛风升阳药以兼顾主要继发病变，配涩肠止泻及止血药以缓解主要症状；因CD腹痛程度较重，则理气药与活血药应用相对偏多，UC腹泻程度较重，且血便较多见，则收涩药与止血药的应用偏多。

Objective to explore the Chinese medicine treatment of Crohn＇sdisease （Crohn＇sdisease, CD） and ulcerative colitis （Ulcerative colitis, UC） and the medication. Methods Collected 52 CD compound prescriptions during 1994 -2012, recorded in the ＂traditional Chinese medicine compound prescription analysis＂ software, the drug types, core drugs, drug on statistical analysis and summarized the characteristics of 256 prescriptions treating UC comparison. Results （ 1 ） The top 9 types of the drugs for CD and UC were the same, the top 4 were followed by tonifying Qi, clearing away heat, regulating qi, exuding dampness medicine, the former for activating blood, releasing exterior, warming interior, astringent, and hemostatic medicinal, the latter were astringent, warming interior, releasing exterior, activating blood, andhemostatic medicinal. （2） the top 10 drugs for treating CD were atractylodes, licorice root, dangshen, angelica, Rhizoma Coptidis, tuckahoe, dried tangerine peel, coix seed, Radix Aucklandiae, for UC, Atractylodes, licorice, Rhizoma Coptidis, Radix Paeoniae Alba, Radix Aucklandiae, Poria, angelica, astragalus, Pericarpium citri Reticulatae; drugs commonly used for treating are the core drugs permutation and combination. Conclusion the study shows that, CD and UC belong to inflammatory bowel disease, TCM prescription treatment of the disease are basically the same, with tonifying qi and invigorating spleen, clearing heat and dampness, promoting urination and draining dampness, warming interior medicine to eliminate pathogeny, combined with qi regulating medicinal, activating blood and resolving stasis medicinal, expelling wind and elevating yang medicine to the secondary lesion, with astringing intestines and checking diarrhea and hemostatic drugs to relieve the main symptoms; for CD abdominal pain is heavy, Qi and promoting blood circulation drugs application is relatively more, UC diarrhea is heavy, and more stool, so use more astringent drug and hemostatic drugs.