期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

E3蛋白:一个重要的痘苗病毒抗干扰素免疫逃避因子 被引量：2

E3 protein: a key anti-interferon immuneevasion factor of vaccinia virus
下载PDF
导出
摘要 痘苗病毒能够对抗宿主的抗干扰素作用是其致病机理中的一个重要方面。E3蛋白是由痘苗病毒编码的一类重要的抗干扰素免疫逃避因子,它通过其羧基末端的dsRNA结合域与dsRNA作用后抑制干扰素产生系统中的PRK、2′,5′-OAS/RNaseL系统和RNA聚合酶Ⅲ介导的抗病毒通路,还能通过抑制ISG15的修饰活性、ADAR1催化腺苷酸转化为次黄嘌呤的编辑活性以及IRF3/7的功能进一步逃避宿主的免疫监控。本文就E3蛋白介导的抗干扰素免疫逃避策略做一简要综述。 Vaccinia virus（VV） can antagonize the anti-interferon（IFN） action of host,which is an important mechanism of VV pathogenesis.E3 protein is a key immune evasion factor encoded by VV,which functions by inhibiting the antiviral pathways mediated by PKR,2′,5′-OAS/RNaseL system and RNA polymeraseⅢ.On the other hand,E3 can also evade the host immunosurveillance through inhibiting the modification activity of ISG15,the A-to-I RNA editing activity of ADAR1 and the activation of IRF3/7.This review focuses on introducing the anti-IFN evasion strategies mediated by E3.
作者 于少雄 颜新敏 张强
机构地区 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室国家口蹄疫参考实验室甘肃省生物检测工程技术研究
出处 《免疫学杂志》 CAS CSCD 北大核心 2013年第10期898-902,共5页 Immunological Journal
基金 国家自然科学基金青年基金项目(31101802) 国家高技术研究发展计划(863计划)项目(2012AA101304)
关键词 痘苗病毒 E3蛋白 免疫逃避 抗干扰素机制 Vaccinia virus E3 protein Immune evasion Anti-IFN mechanism
分类号 R392.1 [医药卫生—免疫学]
  • 相关文献

参考文献28

  • 1Samuel CE.Antiviral actions of interferons[J].Clin MicrobiolRev,2001,14(4):778-809.
  • 2Sen GC.Viruses and interferons [J].Annu Rev Microbiol,2001,55:255-281.
  • 3Honda K,Takaoka A,Taniguchi T.Type I interferon geneinduction by the interferon regulatory factor family oftranscription factor[J].Immunity,2006,25(3):349-360.
  • 4Stetson DB,Medzhitov R.Type I interferons in hostdefense[J].Immunity,2006,25(3):373-381.
  • 5Bowie A,Kiss Toth E,Symons JA,et al.A46R and A52Rfrom vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling [J].Proc Natl Acad Sci USA,2000,97(18):10162-10167.
  • 6Chang HW,Watson JC,Jacobs BL.The E3L gene ofvaccinia virus encodes an inhibitor of the interferon-induced,doublestranded RNA-dependent protein kinase[J].Proc Natl Acad Sci USA,1992,89(11):4825-4829.
  • 7Najarro P,Traktman P,Lewis JA.Vaccinia virus blocksgamma interferon signal transduction:viral VH1phosphatase reverses Statl activation[J].J Virol,2001,75(7):3185-3196.
  • 8Chang HW,Watson JC,Jacobs BL.Identification of aconserved motif that is necessary for binding of thevaccinia virus E3L gene products to double-strandedRNA[J].Virology,1993,75(7):3185-3196.
  • 9Kim YG,Muralinath M,Brandt T.A role for Z-DNAbinding in vaccinia virus pathogenesis [J].Proc Natl AcadSci USA,2003,100(12):6974-6979.
  • 10Ho CK,Shuman S.Physical and functional characterizationof the double-stranded RNA binding protein encoded bythe vaccinia virus E3 gene[J].Virology,1996,217(1):272-284.

二级参考文献36

  • 1Beutler B, Rehli M. Evolution of the TIR, tolls and TLRs: functional inferences from computational biology [J]. Curr Top Microhiol Immunol, 2002, 270( 1 ):1-21.
  • 2Parker LC, Prince LR, Sabroe I. Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity[J]. Clin Exp Immunol, 2007, 147(2): 199-207.
  • 3Eisenbarth SC, Flavell RA. Innate instruction of adaptive immunity revisited: the intlammasome [J]. EMBO Mol Med, 2009, 1(2):92-98.
  • 4Loiarro M, Gallo G, Fant N, et al. Identification of critical residues of the MyD88 death domain involved in therecruitment of downstream kinases[J]. J Biol Chem, 2009, 284(41): 28093-28103.
  • 5Jin MS, Kim SE, Heo JY, et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acy lated lipopeptide[J]. Cell, 2007, 130(6): 1071-1082.
  • 6Hasan U, Chaffois C, Gaillard C, et al. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic ceils, which activates gene transcription through MyD88[J]. J Immunol, 2005, 174(5):2942-2950.
  • 7Thompson JM, Iwasaki A. Toll-like receptors regulation of viral infection and disease [J]. Adv Drug Deliv Rev, 2008, 60(7):786-794.
  • 8Andersen-Nissen E, Smith KD, Bonneau R, et al. A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin[J]. J Exp Med, 2007, 204(2):393-403.
  • 9Oliveira M, Gleeson M. The influence of prolonged cycling on monocyte Toll-like receptor 2 and 4 expression in healthymen[J]. Eur J Appl Physiol, 2010, 109(2):251-257.
  • 10Sorrentino R, Morello S, Bonavita E, et al. The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation[J]. J Cell Physiol, 2010, 223(1):158-167.

共引文献53

同被引文献6

  • 1S.Babiuk,T. R.Bowden,D. B.Boyle,D. B.Wallace,R. P.Kitching.Capripoxviruses: An Emerging Worldwide Threat to Sheep, Goats and Cattle[J].Transboundary and Emerging Diseases.2008(7)
  • 2Carmen Rivas,Jesús Gil,Zora Mělková,Mariano Esteban,Margarita D??az-Guerra.Vaccinia Virus E3L Protein Is an Inhibitor of the Interferon (IFN)-Induced 2-5A Synthetase Enzyme[J].Virology.1998(2)
  • 3J. A. H. Daoud.Sheep pox among australian sheep in Jordan[J].Tropical Animal Health and Production.1997(4)
  • 4M. O. Asagba,D. R. Nawathe.Evidence of sheep pox in Nigeria[J].Tropical Animal Health and Production.1981(1)
  • 5吴海燕,孙秀峰.山羊痘和绵羊痘研究进展[J].动物医学进展,2011,32(12):104-109. 被引量：13
  • 6于少雄,颜新敏,吴国华,赵志荀,卢昌,叶奕优,朱海霞,李健,张强.绵羊痘病毒E3L基因的克隆和表达及其结构分析[J].中国兽医科学,2013,43(9):924-929. 被引量：1

引证文献2

二级引证文献1

免疫学杂志
2013年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部