摘要
正性共刺激分子OX40与多种疾病(如肿瘤、自身免疫性疾病、移植排斥反应等)的发生、发展有关,能促进T细胞的活化和细胞因子的分泌。调节性T细胞通过免疫抑制与免疫耐受机制影响疾病的发展。本文主要就OX40/OX40L与调节性T细胞的关联性及其在病毒、细菌、真菌、寄生虫等病原体引起的感染性疾病中的调节机制的研究进展进行简要综述。
Positive costimulatory molecule OX40,associated with the generation and development of immunologic diseases（such as tumor,autoimmune diseases,anti-transplantation response）,can enhance the activation and augmentation of cytokines secretion of T cells.Regulatory T cells can influence the development of diseases through the mechanism of immunosuppression and immune tolerance.This review mainly delineates the associativity of OX40 and Treg,as well as the regulatory mechanism of OX40/OX40L on infectious diseases evoked by pathogens such as virus,bacterias,fungus and parasites.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2013年第10期903-906,共4页
Immunological Journal
基金
国家自然科学基金(81160200,81060135,30860263,81160378)
