建议暂停羟乙基淀粉在严重烧伤休克期中的应用

A propose to suspend the use of hydroxyethyl starch for flu- id resuscitation in shock phase of severe burns

羟乙基淀粉（hydroxyethylstarch，HES）自20世纪70年代应用以来，被认为较明胶、右旋糖酐等代血浆有更好的扩容效果，因而广泛应用于急诊科、烧伤科、手术麻醉科、ICU等科室中由各种原因所致低血容量患者的治疗。临床所应用的HES主要由土豆、玉米等农作物淀粉经纯化、羟乙基化制成，

Based on the result of randomized controlled trials and meta-analysis recently, the infusion of hydroxyethyl starch （HES） was not shown to overmatch routine crystalline so- lution in exerting resuscitation effect against hypovolemia of pa- tients with burn shock, severe systematic infection, or other crit- ical conditions, on the other hand, it may induce renal toxicity and other toxic and side effects. Since the pathological mecha- nism underlying hypovolemia during shock phase after burn is similar to that of severe systemic infection, we propose to sus- pend the use of HES for fluid resuscitation during the shock phase of severe burn until further elucidation.