期刊文献+

乳腺叶状肿瘤内的小叶瘤变及微小浸润癌临床病理观察 被引量:7

Clinicopathologic features of lobular neoplasis and microinvasive carcinoma in phyllode tumor
下载PDF
导出
摘要 目的探讨叶状肿瘤内出现癌的临床病理学意义。方法复习1例乳腺叶状肿瘤内出现小叶瘤变及浸润癌病例的临床病史和影像学资料,行组织学检查、免疫组化标记并复习文献。结果患者女性,51岁。右侧乳腺肿物。穿刺活检:良性叶状肿瘤,间质假血管瘤样增生明显;局部区域见小叶瘤变,病灶约3个小叶区域,有微小浸润癌出现。免疫组化:小叶瘤变、浸润癌部分和叶状肿瘤间质成分均分别表达上皮系列及间叶系列标记。说明叶状肿瘤和其内出现的浸润癌是两种不同来源的肿瘤。结论叶状肿瘤内出现癌少见,如果出现此类情况提示碰撞瘤的存在,如果是恶性叶状肿瘤就有可能存在癌肉瘤。但良性叶状肿瘤中出现灶状浸润癌成分不应归类为癌肉瘤,应视为碰撞瘤。 Objective To explore the invasive carcinomas arising in phyllodes tumor representing an uncommon manifestation of breast cancer. Methods We report the ease of a 51-year-old woman who underwent mammary biopsy for a benign phyllodes tumor measuring 11 era. Results I-Iistologieal workup of the specimen revealed lobular neoplasis and perhaps with mieroinvasive carcinoma about three ]obular areas with a invasive area 1 mm in diameter within the phyllodes tumor. The results of IHC showed that lobular neoplasis, invasive caneinomas and the stromal components of phyllodes tumor were positve for epithelial markers and stromal markers, respectively, suggesting the phyllodes tumor and the invasive eaneinomas in it comes from different origin. The papers reports also shows there are different gene mutation in epithelial and stromal components in same kind eases. Conclusion The coexisting of phyllodes tumor and carcinoma appears to represent a true collision tumor, and the existence of carcinoma within a malignant phyllodes tumor has been proposed to qualify for the designation of true carcinosareoma of the breast.
出处 《诊断病理学杂志》 CSCD 北大核心 2013年第9期560-563,共4页 Chinese Journal of Diagnostic Pathology
关键词 乳腺 叶状肿瘤 小叶瘤变 碰撞瘤 癌肉瘤 Breast Phyllode tumor Lobular neoplasis Cancer Collode tumor Carcinosarcoma
  • 相关文献

参考文献13

  • 1阿克曼.乳腺及女性生殖器官肿瘤病理学和遗传学[M].程红等译.北京:人民卫生出版社,2008.119-122.
  • 2Abe M, Miyata S, Nishimura S, et al, Malignant transformation of breast fibroadenoma to malignant phyllodes tumor; long-term outcome of 36 malignant phyllodes tumors [ J ]. Breast Cancer, 2011,18(4) :268 -272.
  • 3Kuijper A, Buerger H, Simon R, et al. Analysis of the progression of fibroepithclial tumours of the breast by PCR-based clonality assay[J]. J Pathol, 2002,197(5) : 575 -581.
  • 4Kuijper A, Snijders AM, Berns EM, et aL Genomic profling by array comparati-e genomie hybredization re-eals no-el DNA copy number changes in phyllodes tumors and lack of alterations in fibroadenomas[ J ] Cell Oncol, 2009, 31 ( 1 ) ;31 - 39.
  • 5Hodges K, Abdul-Karim F, Wang M, et al. E-idence for transformation of fibroadenoma of the breast to malignant phyllodes tumor[J]. Appl Immunohist Mol Morphol, 2009, 17 (4) : 345 -350.
  • 6Sasa M, Morimoto T, Ii K, et al. A malignant phyllodes tumor of the breast in a 6-year old girl[ J]. Breast Cancer, 1995,2( 1 ) : 71 -75.
  • 7Sawyer EJ, Hanby AM, Ellis P, et al. Molecular analysis of phyllodes tumors re-eals distinct changes in the epithelial and stromal components [ J ]. Am J Pathol, 2000, 156 (3) : 1093 - 1098.
  • 8Jara-Lazaro AR, Tan PH. Molecular pathogenesis of progression and recurrence in breast phyllodes tumors [ J ]. Am J Transl Res, 2009,1 ( 1 ) ;23 -34.
  • 9Parker S J, H arries SA. Phyllodes tumours [ J ] Postgrad Med J,2001, 77(909) : 428 - 435.
  • 10Tse GM, Lee CS, Kung FY, et al. Hormonal receptors expression in epithelial ceils of mammary phyllodes tumors correlates with pathologic grade of the tumor: a multicenter study of 143 cases[J]. Am J Clin Pathol, 2002, 118(4) :522 -526.

共引文献1

同被引文献23

  • 1戴敏,杨文涛.乳腺癌肉瘤1例报道及文献复习[J].临床与实验病理学杂志,2005,21(4):469-471. 被引量:5
  • 2吕淑华,牛昀.乳腺叶状肿瘤[J].中国肿瘤临床,2006,33(3):175-178. 被引量:25
  • 3阿克曼.乳腺及女性生殖器官肿瘤病理学和遗传学[M].程红等译.北京:人民卫生出版社,2008.119-122.
  • 4Parfitt JR, Armstrong C, O' malley F, et al. In-situ and invasive carcinoma within a phyllodes tumor associated with lymph node metastases [ J]. World J Surg Oncol, 2004, 2:46.
  • 5Neto GB, Rossetti C, Souza NA, et al. Coexistence of benign phyllodes tumor and invasive ductal carcinoma in distinct breasts: case report [J]. Eur J Med Res, 2012, 17:8.
  • 6Sugie T, Takeuchi E, Kunishima F, et al. A case of ductal carcinoma with squamous differentiation in malignant phyllodes tumor [J]. Breast Cancer, 2007, 14(3) :327-332.
  • 7Quinlan-Davidson S, Hodgson N, Elavathil L, et al. Borderline phyllodes tumor with an incidental invasive tubular carcinoma and lobular carcinoma in situ component: a case report [ J ]. J Breast Cancer, 2011,14 (3) :237-240.
  • 8Merck B, Cansado Martinez P, Perez Ramos M, et al. Infiltrating ductal carcinoma and synchronous malignant phyllodes tumour. Diagnostic and therapeutic approaches [ J ]. Clin Transl Oncol, 2006, 8( 11 ) :830-832.
  • 9Auerbach L. Concomitant phyllodes tumour and homolateral breast cancer [J]. Lancet Oncol, 2002, 3(5) :279.
  • 10Nio Y, Ignchi C, Tsuboi K, et al. Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report with a review of the literature [J]. Oncol Lett, 2011, 2(2) :223-228.

引证文献7

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部