苯磺酰苯丙氨酸构筑的一维链状钙(Ⅱ)配位聚合物的合成、结构表征和抗肿瘤活性(英文)

Synthesis, Crystal Structure and Antitumor Activity of Ca(Ⅱ) Coordination Polymer Constructed by N-Benzenesulphonyl-L-phenylalanine

在95%乙醇溶剂中,通过高氯酸钙、苯磺酰苯丙氨酸和NaOH反应,合成了一个新型的一维链状钙配位聚合物。对其进行了元素分析和红外光谱分析表征,并用X-射线单晶衍射测定了它的单晶结构。结果表明:在配合物分子中,每个钙原子分别与配体中羧酸根的4个氧原子、配位水中的2个氧原子以及配位乙醇分子中的1个氧原子配位,形成了畸变的五角双锥构型。配合物分子通过羧酸根的桥联作用形成了一维链状配位聚合物结构。初步研究了配合物对肝癌、肺腺癌、白血病和结肠癌的抗肿瘤活性。

Colourless crystals of 1D coordination polymer, [Ca（L）2（HEO）E（CH3CH2OH）]n （L=N-benzenesulphonyl-L- phenylalanine）, were obtained by the reaction of calcium perchlorate and N-benzenesulphonyl-L-phenylalanine in the 95% CH3CH：OH solution, and characterized by elemental analysis, IR and X-ray single crystal diffraction analysis. The single-crystal X-ray analysis of the title complex reveals that each Ca（Ⅱ） atom is seven-coordinated in a distorted pentagonal bipyramid coordination environment by seven oxygen atoms from the N- benzenesulphonyl-L-phenylalanine ligand, the coordinated water molecule and the coordinated CH3CH2OH molecule, respectively. The molecular structure is 1D coordination polymer by the interaction of bridged carboxylato groups. The antitumor activity against SMMC-7721, A549, WiDr and P388 cancer cells of the Ca（H） complex also was investigated. CCDC： 890991.