血清AFU和ADA联合检测在2型糖尿病控制中的临床意义

The clinic significance of combined detection of serum AFU and ADA in patients with type 2 diabetes mellitus

目的探讨血清α-L-岩藻糖苷酶(AFU)和腺苷脱氨酶(ADA)联合检测在2型糖尿病病情控制中的临床意义。方法选取济南市434例2型糖尿病患者和94例正常对照人员进行血清AFU和ADA测定。根据糖化血红蛋白(HbA1c)水平高低,将434例糖尿病患者分为血糖控制不良组(HbA1c>9.0%)、血糖控制一般组(7.0%≤HbA1c<9%)和血糖控制良好组(HbA1c<7.0%),比较2型糖尿病各组和正常对照组间AFU、ADA和相关指标的差异,并分析AFU、ADA与FPG和HbA1c的相关性。结果经单因素方差分析和Pearson相关分析,2型糖尿病患者糖尿病组和血糖控制不良组AFU和ADA活性显著高于正常对照组〔(23.29±2.17)vs(15.37±1.57);(23.61±3.07)vs(14.85±3.64),P<0.05〕,并且与糖化血红蛋白(HbA1c,r AFU=0.348,r ADA=0.385,P<0.01)和空腹血糖水平(FPG,r AFU=0.296,r ADA=0.385,P<0.01)呈正相关。血糖控制一般组和良好组与正常对照组组间差异比较无统计学意义(P>0.05),但是AFU和ADA活性仍高于正常对照组。结论 AFU和ADA在血糖控制不良时明显偏高,并且分别与HbA1c和FPG明显相关,可以作为2型糖尿病血糖控制和病情监测的指标。

Objective To investigate the clinic significance of combined detection of serum α-L-fucosidase （AFU） and adenosine deaminase （ADA） in patients with type 2 diabetes mellitus （T2DM）,Methods 434 patients with T2DM （set to T2DM group） were divided into hyperglycemia poorly controlled （HbA1 c ＞ 9.0％）,hyperglycemia normally controlled （7.0％ ≤ HbA1 c ＜ 9％）,hyperglycemia well controlled groups（HbA1c ＜ 7.0％）.Subjects of the three groups and 94 normal control subjects（set to NC group） were selected to measure the serum AFU and ADA levels,to compare the difference of the measured index between each group of T2DM groups and NC group,and to analyze the relevance of the measured index and glucose results.Results The levels of AFU and ADA in T2DM group and hyperglycemia poorly controlled group were obviously higher than those of normal subjects （P ＜ 0.05）.The levels of AFU and ADA showed positive correlation with HbA1c and FPG.The levels of serum AFU and ADA in both normally controlled group and hyperglycemia well controlled group had no obvious differences with those in NC group（P ＞ 0.05）,but still slightly higher than those of NC group.Conclusions In hyperglycemia poorly controlled group the levels of AFU and ADA are obviously higher and have obvious correlation with HbA1c and FPG respectively and they could be used as the indicators of blood glucose control and condition monitoring in T2DM.